Yolk sac tumor in an antenatal patient: a challenging case

Anu Namgyal, Anjali Soni, Suresh Verma, Indu Chauhan, Shikha Sharma, Charu Purbia


Pregnancy complicated with adnexal masses is a very common occurrence. However, most of these adnexal masses encountered in pregnancy are benign in nature and are found incidentally during routine antenatal ultrasound. Malignant ovarian neoplasms account for 1%-8% of all persistent adnexal masses diagnosed during pregnancy. Yolk sac tumor (YST) complicating pregnancy is very rare and has no proper guidelines for its diagnosis and management hence causing a therapeutic dilemma for the clinicians. Therefore, an individualised approach is preferred in such cases. It is very important to report such cases for better understanding and management of these cases. Here we present a case report of a 23-year-old primigravida at 30 weeks gestation with yolk sac tumor of right ovary, surgical stage IIIc who responded well to fertility sparing surgery with cisplatin-based combination chemotherapy. She has no evidence of disease post treatment and has been put on regular follow up.


Endodermal sinus tumor, Germ cell tumor, Ovarian malignancy, Pregnancy, Yolk sac tumor

Full Text:



De Haan J, Verheecke M, Amant F. Management of ovarian cysts and cancer in pregnancy. Facts, Views and Vision in Obstet Gynecol. 2015;7(1):25-31.

Yakasai IA, Bappa LA. Diagnosis and Management of Adnexal Masses in Pregnancy. Journal of Surgical Tech Case Report. 2012;4(2):79-85.

Bromley B, Benacerraf B. Adnexal masses during pregnancy: accuracy of sonographic diagnosis and outcome. J Ultrasound Med. 1997;16(7):447-52.

Kort B, Katz VL, Watson WJ. The effect of nonobstetric operation during pregnancy Surg Gynecol Obstet. 1993;177(4):371-6.

Low JJ, Perrin LC, Crandon AJ, Hacker NF. Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. A review of 74 cases. Cancer. 2000;89(2):391-8.

Elit L, Bocking A, Kenyon C, Natale R. An Endodermal Sinus Tumor Diagnosed in Pregnancy: Case Report and Review of the Literature. Gynecol Oncol. 1999;72(1):123-7.

Quirk JT, Natarajan N. Ovarian cancer incidence in the United States, 1992e1999. Gynecol Oncol 2005;97(2):519e23.

Willemse PH, Aalders JG, Bouma J, Mulder NH, Verschueren RC, DeVries EG, et al. Long-term survival after vinblastine, bleomycin, and cisplatin treatment in patients with germ cell tumors of the ovary: an update. Gynecol Oncol. 1987;28(3):268e77.

Cicin I, Saip P, Guney N, Eralp Y, Ayan I, Kebudi R, et al. Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors. Eur J Obstet Gynecol Reprod Biol 2009;146(2):210e4.

de La Motte Rouge T, Pautier P, Duvillard P, Rey A, Morice P, Haie-Meder C, et al. Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. Ann Oncol 2008;19(8):1435e41.