Uric acid as an important biomarker in hypertensive disorders in pregnancy

Triveni Kondareddy; Prathap T.

doi:10.18203/2320-1770.ijrcog20164348

Authors

Triveni Kondareddy Department of Obstetrics and Gynecology, JSS Medical College, Mysore, Karnataka, India
Prathap T. Department of Obstetrics and Gynecology, JSS Medical College, Mysore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20164348

Keywords:

Eclampsia, Maternal outcome, Pre-eclampsia, Perinatal outcome, Uric acid

Abstract

Background: Hypertension in pregnancy is a global problem and complicates approximately 10-17% of pregnancies. The incidence of PIH in India ranges from 5% to 15%. Uric acid is a marker of oxidative stress, tissue injury and renal dysfunction and therefore might be helpful in the prediction of complications of PE. Literature on serum uric acid as a predictor of complications of PE is conflicting. The present is intended to study uric acid as an important biomarker in hypertension in pregnancy.

Methods: This was prospective observational analytical case control study of 180 individuals done at JSS Hospital, Mysore, India from January 2015 to July 2016.

Results: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy (p <0.01). Hypertensive mothers with uric acid levels >6.0mg/dl shows 100% maternal deaths, 79.4% with eclampsia and 71.9% with preterm delivery.

Conclusions: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy. Hyperuricemia in patients with hypertensive disorders of pregnancy is a strong risk factor for several maternal and perinatal complications.