DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20184964

Pregnancy outcome in women with previous preeclampsia versus women normotensive in previous pregnancy

Jayshree Mulik, Snehalata Suresh

Abstract


Background: Women with history of preeclampsia have reportedly higher risk of development of preeclampsia in subsequent pregnancies, along with other adverse pregnancy outcomes. Authors aimed to study the incidence of recurrent preeclampsia and compare the pregnancy outcome in women with history of preeclampsia in previous pregnancy with those who were normotensive in previous pregnancy and further compare outcomes in women with recurrent preeclampsia between their previous and index pregnancy.

Methods: Pregnancy outcome was studied in women with preeclampsia in previous pregnancy (cases) and compared with women normotensive in previous pregnancy (controls). Further analysis of cases was done by dividing them into subgroups: those with recurrent preeclampsia in index pregnancy (A1) and those normotensive in index pregnancy despite being pre-eclamptic in previous pregnancy (A2). Total 100 cases and 100 controls were enrolled in the study, which was conducted at present tertiary care centre from January 2012 to June 2013.

Results: Out of total 200 participants (100 cases, 100 controls) enrolled in the study; 58 out of 100 cases had recurrent preeclampsia and remaining 42 remained normo-tensive in index pregnancy. Among 100 controls, 93 were normotensive in index pregnancy.

Conclusions: Women with history of preeclampsia in previous pregnancy had adverse maternal and perinatal outcome in subsequent pregnancy when compared to the women who were normotensive in the previous pregnancy. But when compared with their own previous preeclamptic pregnancy, they had better pregnancy outcome with good perinatal outcome in their index pregnancy.

 


Keywords


Perinatal outcome, Preeclampsia, Recurrent preeclampsia

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References


Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005;365:785-99.

Sibai B. Prevention of preeclampsia: a big disappointment. Am J Obstet Gynaecol. 1998;179:1275-8.

Hjartardottir S, Leifsson BG, Geirsson RT, Stenthorsdottir V. Recurrence of hypertensive disorder in second pregnancy. Am J Obstet Gynecol. 2006;194:916-20.

Van Rijn BB, Hocks LB, Bots ML, Franx A, Bruinse HW. Outcome of subsequent pregnancies with early onset preeclampsia. Am J Obstet Gynecol. 2006;195:723-8.

Sibai B, Mercer B, Sarinoglu C. Severe preeclampsia in second trimester: recurrence risk and long term prognosis. Am J Obstet Gynecol. 1991;165:1408-12.

Report of the National High Blood Pressure. Education Programme Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol. 2000;183:S1-22.

Hnat MD, Sibai B, Cartitis S. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol. 2002;186:422-6.

Cartitis S, Sibai B, Hauth J, Lindheimer MD, Klebnoff M, Thom E, et al. Low dose Aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med. 1998;338:701-5.

Chen YY, Wu ML, Kao MH, Su TH, Chen CP. Perinatal outcome of recurrent preeclampsia versus preeclampsia in nulliparas. J Obstet Gynecol. 2009;35(9):1042-6.

Sibai B, El-Nazer A, Gonzales-Ruiz A. Severe preeclampsia-eclampsia in young primigravida women: Subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol. 1986;155:1011-6.

Bramham K, Annette L, Seed P, Lucilla P, Andrew H, Lucy C. Adverse maternal and perinatal outcome in women with previous preeclampsia: a prospective study. Am J Obstet Gynecol. 2011;204(6):512-9.

Makkonen N, Heinonen S, Kirkinen P. Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy; Kuopio University, Finland. Hypertens Preg. 2000;4:34-8.

Mendilcioglu I, Trak B, Uner M, Umit S, Kucukosmanoglu M. Recurrent preeclampsia and perinatal outcome: a study of women with recurrent preeclampsia who remained normotensive during their prior pregnancies. School of Medicine, Akdeniz University, Antalya, Turkey. Acta Obst. Gynecol Scand. 2004;83:1044-8.