DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20184245

Study of effectiveness, tolerability and safety of intravenous iron sucrose in iron deficiency anaemia in postnatal women

R. Niranjana, K. S. Raja Rajeswari

Abstract


Background: Iron deficiency anaemia is the most common type of reversible anemia encountered during pregnancy and postpartum period. The present study was done with the objective to find out the efficacy and safety of intravenous iron sucrose in the treatment of iron deficiency anaemia in the postpartum period.

Methods: Fifty (50) postnatal patients both after vaginal and caesarean section with iron deficiency anaemia within the first 48 hours with haemoglobin percentage between 6 g/dl and 8g/dl were studied prospectively at the Institute of Obstetrics and Gynaecology, Madras Medical College, Chennai. The patients were given 100 mg of elemental iron diluted in 100 ml of 0.9% normal saline and infused over 15 minutes every alternate day (not more than 3 days in a week) until the required dosage is infused. The blood samples of all the patients were collected and analyzed for haemoglobin (g/dl), hematocrit, mean corpuscular volume (MCV), serum iron, total iron binding capacity (TIBC) and compared before and after therapy.

Results: The mean age group of the patients was 24.94 years. Majority of the patients were multipara (68%) and belongs to the class V socio economic status (84%). All the blood parameters were increased significantly (p=0.000) when compared from baseline values to end of the treatment. Mean raise in haemoglobin% after 30 days of treatment was 3.60. Average raise in the mean hematocrit was 8.73. The mean difference in the mean corpuscular volume, total iron binding capacity and the percent saturation was 129.77, 13.55, was 22.26 respectively.

Conclusions: Our data confirm that the intravenous iron sucrose was very effective, well tolerated and safe than other forms of iron preparations for treating iron deficiency anaemia in postnatal women.


Keywords


Intravenous iron-sucrose complex, Iron deficiency anaemia, Post-natal women

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References


Bashiri A, Burstein E, Sheiner E, Mazor M. Anaemia during pregnancy and treatment with intravenous iron; Review of literature. Eur J Obstet gynaecol Reprod Biol. 2003;110:2-7.

World Health Organisation. Report of a WHO group of experts on nutritional anaemia. Technical report series no.503: WHO, 1972.

Alleyne M, Horne MK, Miller JL. Individualized treatment for iron-deficiency anemia in adults. Am J Med. 2008;121(11):943-8.

Cançado RD, Lobo C, Friedrich JR. Tratamento da anemia ferropriva com ferro via oral. Rev Bras Hematol Hemoter. 2010;32(2):114-20.

Breymann C. Treatment of iron deficiency anaemia in pregnancy and postpartum with special focus on intravenous iron sucrose complex. J Med Assoc Thai. 2005;88:108-9.

Cançado RD, de Figueiredo PO, Olivato MC, Chiattone CS. Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia. Rev Bras Hematol Hemoter. 2011;33(6):439-43.

Giannoulis C, Daniilidis A, Tantanasis T, Dinas K, Tzafettas J. Intravenous administration of iron sucrose for treating anemia in postpartum women. Hippokratia. 2009;13(1):38-40.

Bhandal N, Russell R. Intravenous versus oral iron therapy for postpartum anaemia. BJOG. 2006;113:1248-52.

Gravier A, Descargues G, Marpeau L. Comment eviter les transfusions dans le post-partum interet d' une supplementation martiale par voie intraveineuse. J Gynecol Obstet Biol Reprod. 1999;28:77-8.

Dede A, Uygur D, Yilmaz B, Mungan T, Ugur M. Intravenous iron sucrose complex versus oral ferrous sulphate for postpartum iron deficiency anaemia. Int J Gynaecol Obstetrics. 2005;90:238-9.

Raja KS. Intravenous iron sucrose complex therapy in iron deficiency anaemia in the pregnant women. J Pakistan Med Assoc. 2003;28.

Messer J, Escande B, Matis J. Erythropoietin and iron in the anemia of prematurity. TATM. 19991:15-7.

Petewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with iron-sucrose complex. Br J Nutr. 2002;88:3-10.

Bailie G, Clark J, Lane CE, Lane PL. Hypersensitivity reactions and deaths associated with intravenous iron preparations. Nephrol Dial Transplant. 2005;20:1443-9.