Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

Rashid Lodhi, Navanil Roy


Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.

Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema.  Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.

Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls,  it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.

Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.


Hypertension, Liver function Test (LFT), Morbidity, Pre-eclampsia, Pregnancy, Women

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Coppage KH, Sibai BM. Treatment of hypertensive complications in pregnancy. Curr Pharm Des. 2005;11(6):749-57.

Romero R, Vizoso J, Emamian M, Duffy T, Riely C, Halford T, et al. Clinical significance of liver dysfunction in pregnancy-induced hypertension1. Am J Perinatol. 1988;5:146-51.

Verhaeghe J, Anthony J, Davery DA. Platelet count and liver function tests in protein uric and chronic hypertension in pregnancy. S Afr Med J. 1990;79:590-4.

Bhowik DK, Akhtari R, Saha M, et al. Alteration of liver function in preeclampsia and eclampsia. CMOSH Med Coll J. 2013;12(3):9-10.

National High Blood Pressure Education Programme Working Group on High Pressure in pregnancy. Report of the National High Blood Pressure Education program. Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183(1):S1-22.

Davey DA, Mac Gillivray. The Classification and definition of the hypertensive disorders of pregnancy; Am J Obstet Gynecol. 1988;158:892-8.

Angel Gracia AL. Effect of pregnancy on pre-existing liver disease. Physiological changes during pregnancy. Ann Hepatol. 2000;5(3):184-6.

Burroughs AK. Pregnancy and liver disease. Forum (Genova). 1998;8(1):42-58.

ACOG Committee on Obstetric Practica. ACOG Practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002;99(1):159-67.

Lopez-Jaramillo P, Casas JP, Serrano N. Preeclampsia from epidemiological observation to molecular mechanism. Broz J Med Biol Res. 2001;34(10):1227-35.

Malvino E, Munoz M, Ceccottic C, Janello G, Mc Loughlin D, Pawlak A, et al. Maternal morbidity and perinatal mortality in HELLP syndrome (Multicentric studies in intensive care units in Buenos Aires area). Medicina (B. Aires). 2005;65(1):17-23.

Jaleel A, Baseer A, Aamir S. Biochemical parameters for detection of hemolysis in pregnancy induced hypertensive woman. J Coll Physicians Surg Pak. 1999;9(1):41-2.

Rath W, Faridi A, Dudenhausen JW. HELLP Syndrome. J Perinat Med. 2000;28(4):249-60.

Kim JH, Kwon CI, Ko EH, Kim DY, Kim HY, Jung SH, et al. Abnormal liver function tests in pregnancy. Korean J Gastroenterol. 2007;50(1):36-41.