C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study

Tarek A. Farghaly; Neveen A. Helmy; Ahmed M. Abbas; Abdel Ghaffar M. Ahmed

doi:10.18203/2320-1770.ijrcog20184922

Authors

Tarek A. Farghaly Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Neveen A. Helmy Department of Obstetrics and Gynecology, Sahel Selim Hospital, Assiut, Egypt
Ahmed M. Abbas Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abdel Ghaffar M. Ahmed Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20184922

Keywords:

C-reactive protein, Gestational diabetes mellitus, Glucose tolerance test

Abstract

Background: The current study aims to determine if increased inflammation identified by increased C-reactive protein (CRP) level is associated with the subsequent development of gestational diabetes mellitus (GDM).

Methods: A prospective cohort study conducted at a tertiary University Hospital included 496 booking for their antenatal care visit between 10-12 weeks of gestation. They were tested for presence of CRP in blood. All women without a history of antenatal type 1 or type 2 diabetes undergo routine GDM screening with the 50-g oral glucose-loading test (GLT) between 24 and 28 weeks 'gestation. Women whose 1-h post-loading plasma glucose level >7.8 mmol/l (>140 mg/dl) undergo a diagnostic, fasting, 100-g, 3-h oral glucose tolerance test (OGTT) within 1-2 weeks following the GLT.

Results: Among these 496 women, a total of 27 women (5.4%) were diagnosed as GDM and 10 women (2.0%) were diagnosed as IGT at week 24-28. The CRP was positive and higher in the GDM diagnosed group (p=0.000) compared to those who did not develop GDM. CRP was positively correlated with diagnosis of GDM (r=0.438, p=0.012).

Conclusions: There is an association between first-trimester inflammation, marked by increased CRP levels and subsequent risk of GDM.

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