DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20185427

Association of maternal plasma or serum zinc concentration with the birth weight of the child

Girija C. Bellad, Laxmi K. S.

Abstract


Background: Zinc is a divalent cation first isolated in 1509 and since then its importance has been increasingly recognised in human health and nutrition. Present study has been undertaken to confirm the association between maternal plasma or serum zinc concentration and birth weight.

Methods: Present study was cross-sectional study conducted in tertiary care hospital. Newborns with a birth weight of < 2.5kg and their mothers labelled as study group while newborns with a birth weight of > 2.5kg and their mothers were considered as control group. The analysis for the serum concentration of zinc was done using the Atomic Absorption Spectrophotometric method (AAS), this method analytically the most reliable for routine assessment of serum zinc levels. The results deduced from the analysis were accordingly grouped to the study group / control group. We had a sub-group analysis based on the gestational age, as Preterm and Term.

Results: Maternal serum levels of zinc 67.04 μg /dl±16.66, in the study group, was less as compared to the maternal serum levels of zinc in the control group with a mean level of 75.39 μg/dl±17.89. The results show a significant association between zinc levels and birth weight. Mean Maternal serum levels of zinc 67.04 μg /dl±16.66, in the study group, was less as compared to the maternal serum levels of zinc in the control group with a mean level of 75.39 μg/dl±17.89. The results show a significant association between zinc levels and birth weight.

Conclusions: Present study showed a positive correlation of maternal zinc levels with birth weight and prematurity. Hence, we recommend routine zinc supplementation could be included with other nutritional supplements during pregnancy.


Keywords


Birth weight, Cross-sectional pregnancy, Zinc

Full Text:

PDF

References


Prasad AS: Zinc deficiency in women, infants and children. J Am Coll Nutri. 1996;15(2):113-20.

Etemad K, Yavari P, Mehrabi Y, Haghdoost A, Motlagh ME, Kabir MJ, et al. Inequality in utilization of in-patient’s health services in Iran. Int J Prev Med. 2015;6:45.

Moradi-Lakeh M, Vosoogh-Moghaddam A. Health sector evolution plan in Iran; equity and sustainability concerns. Int J Health Policy Manag. 2015;4(10):637-40.

Moradi-Lakeh M, Namiranian N. Increasing trend of low birth weight in rural areas of Iran: a warning. Iran J Pediatr. 2013;23(1):123-4.

Caulfield LE, Zavaleta N, Shankar AH, Merialdi M: Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. Am J Clini Nutri 1998;68(2):499S-508S.

Vinayak M: Comparison Of Maternal Serum And Neonatal Cord Blood Levels Of Zinc In Relation To Birth Weight And Period Of Gestation. 2009.

King JC: The risk of maternal nutritional depletion and poor outcomes increases in early or closely spaced pregnancies. J Nutri. 2003;133(5):1732S-6S.

Erenel H, Mathyk BA, Sal V, Ayhan I, Karatas S, Koc Bebek A. Clinical characteristics and pregnancy outcomes of Syrian refugees: a case–control study in a tertiary care hospital in Istanbul, Turkey. Arch Gynecol Obstet. 2017;295(1):45-50.

Linsell L, Malouf R, Morris J, Kurinczuk JJ, Marlow N. Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review. Dev Med Child Neurol. 2016;58(6):554-69.

Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013; 382(9890):427-51.

Osendarp SJ, Van Raaij JM, Darmstadt GL, Baqui AH, Hautvast JG, Fuchs GJ: Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomized placebo-controlled trial. The Lancet 2001; 357(9262):1080-5.

Palomba S, Santagni S, Daolio J, Gibbins K, Battaglia FA, La Sala GB et al Obstetric and perinatal outcomes in subfertile patients who conceived following low technology interventions for fertility enhancement: a comprehensive review. Arch Gynecol Obstet. 2018:1-15.