DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20185443

A prospective analysis of polycystic ovarian syndrome in infertile women

Soumya Patil, Saraswathi Ramesh, Harinath Srinivasa Murthy Kharidhi

Abstract


Background: Polycystic ovarian syndrome (PCOS) is a frequently occurring metabolic and reproductive endocrinopathy. Young women with PCOS mainly present with reproductive problems such as hyperandrogenism, menstrual irregularities, infertility and chronic anovulation. Despite its high prevalence and implications on reproductive health, PCOS is underdiagnosed. The objective was to study the prevalence of PCO in women with infertility, their symptomatology, endocrine profiles and coexisting factors of infertility in women with PCOS.

Methods: A prospective study was performed over a period of 6 months. Women presenting with infertility were subjected to detailed history taking, general and gynecological examination. Women with features of PCOS on ultrasound were identified and advised investigations such as serum FSH, LH, prolactin and laparoscopy when indicated.

Results: During the study period, 102 patients consulted the infertility clinic, out of which 56 were diagnosed with PCOS. The prevalence of PCOS was found to be 54.9% among infertile women. Menstrual irregularity was found in 33 (59%) women, however, 23 (41%) had regular menstrual cycles. 4 among the 33 patients complained of dysmenorrhea, 5 had heavy menstrual bleeding. On examination, 19 (33.9%) were found hirsute, 8 (14.28%) had thyroid enlargement and 2 (3.57%) had galactorrhea. Investigations revealed mean FSH and LH levels of 8.7±2SD and 13.7±2SD respectively and mean LH/FSH ratio of 1.57±2SD.

Conclusions: PCOS is a heterogenous disorder and with its high prevalence in infertile women, proper diagnosis and management is essential as it has many potential metabolic and cardiovascular risks if not managed appropriately.


Keywords


Hyperandrogenism, Hirsutism, Infertility, Laparoscopy in PCOS, PCOS, Serum Values of FSH and LH in PCOS, Symptoms of PCOS

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References


Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinic. 2015;70(11):765-9.

Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clinic Epidemiol. 2014;6:1.

El Hayek S, Bitar L, Hamdar LH, Mirza FG, Daoud G. Poly cystic ovarian syndrome: an updated overview. Front Physiol. 2016;7:124.

Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage. J Clinic Endocrinol Metabol. 2015;100(3):911-9.

Bruyneel A, Catteau-Jonard S, Decanter C, Clouqueur E, Tomaszewski C, Subtil D, et al. Polycystic ovary syndrome: what are the obstetrical risks?. Gynecol Obstet Fertil. 2014;42(2):104-11.

Kamangar F, Okhovat JP, Schmidt T, Beshay A, Pasch L, Cedars MI, et al. Polycystic ovary syndrome: special diagnostic and therapeutic considerations for children. Pediatr Dermatol. 2015;32(5):571-8.

Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards 417 a rational approach. Polycyst. 1992;418:377-84.

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91(2):456-88.

Fr DD, Tarlatzis R. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1).

Witchel SF, Oberfield S, Rosenfield RL, Codner E, Bonny A, Ibáñez L, et al. The diagnosis of polycystic ovary syndrome during adolescence. Hormone Res Paediatr. 2015;83(6):376-89.

Ramani BV, Subbaiah MV, Devi VR, Umira SA, Keerthi KV, Priya SH. Fertility problems in women with polycystic ovary syndrome. Int J Reprod Contracept Obstet Gynecol. 2017;4(3):560-5.

Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clinic Epidemiol. 2014;6:1.

Panchuk K, Lynam MJ. Polycystic Ovary Syndrome: Appreciating the Complexities and Implications of Diagnosis for Primary Care. UBC Med J. 2012;4(1).

Jalilian N, Haghnazari L, Rasolinia S. Leptin and body mass index in polycystic ovary syndrome. Ind J Endocrinol Metabol. 2016;20(3):324.

Gupta M, Singh D, Toppo M, Priya A, Sethia S, Gupta P. A cross sectional study of polycystic ovarian syndrome among young women in Bhopal, Central India. Int J Comm Med Public Health. 2017;5(1):95-100.

Butterworth J, Deguara J, Borg CM. Bariatric surgery, polycystic ovary syndrome, and infertility. J Obes. 2016;2016.

Choudhary A, Jain S, Chaudhari P. Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?. Int J Reprod, Contracept, Obstet Gynecol. 2017;6(11):4971-5.

Geetha K, Bijoy E, Hisham M. A Cross Sectional Study on Polycystic Ovary Syndrome in South Indian Population. Editorial 133 Research Articles. 2013:140.

Khanam K, Parvin M. An Observational Study on 100 Patients with Polycystic Ovarian Syndrome (PCOS). J Enam Med College. 2014;4(3):156-60.