Predictive value of uterine artery: peak systolic velocity on the day of trigger for clinical pregnancy rate in infertile women


  • Karishma Makhija Department of Obstetrics and Gynecology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India
  • Deepti Shrivasatava Department of Obstetrics and Gynecology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India
  • M. Tiwari Department of Obstetrics and Gynecology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India



2D power colored doppler, Intrauterine insemination, Invitro fertilization, Peak systolic velocity (PSV), Timed intercourse, Uterine artery (UA)


Background: The purpose of the study is to evaluate the role of uterine artery blood flow parameter measured by uterine artery two-dimensional (2D) power coloured doppler (PCD) ultrasound in predicting fertility outcomes in women undergoing ART treatment.

Methods: It is prospective observational study. Total of 60 patients were included  of receiving infertility treatment in the age group20-40 years. 20 patients were selected for timed intercourse , 20 patients were selected for intrauterine insemination , 20 patients were selected for invitro fertilization. Transvaginalsonography will be done on the day of trigger by BHCG , UA PSV were measured,  and endometrial blood flow will be assessed. Predictivity of pregnancy rate  will be looked after by 3 ways: BHCG values  , UPT, Gestational sac  on USG.

Results: In TI/IUI/IVF cycles the Doppler parameter PSV of uterine artery (23.08+/-3.39 vs 20.37-/+5.43) in pregnant vs non-pregnant group did not differ significantly. The mean PSV   of UA shows no significant difference women who were became pregnant during treatment and the women who were not became pregnant.

Conclusions: With help of Doppler parameter imaging of women undergoing infertility it was found that UA PSV is non-significant to decide the prediction of pregnancy outcome.


National center for chronic disease prevention and health promotion Assisted reproductive technology. Atlanta (GA): US Dept of Health and Human Services; 2014:82.

Gelbaya TA, Potdar N, Jeve YB, Nardo LG. Definition and epidemiology of unexplained infertility. Obstet Gynecol Surv. 2014;69(2):10915.

Mishra VV, Agarwal R, Sharma U, Aggarwal R, Choudhary S, Bandwal P. Endometrial and subendometrial vascularity by three-dimensional (3D) power Doppler and its correlation with pregnancy outcome in frozen embryo transfer (FET) cycles. J Obstet Gynecol India. 2016;66(1):521-7.

Salle B, Bied-Damon V, Benchaib M, Desperes S, Gaucherand P, Rudigoz RC. Preliminary report of an ultrasonography and colour Doppler uterine score to predict uterine receptivity in an in-vitro fertilization programme. Hum Reprod. 1998;13(6):1669-73.

Steer CV, Tan SL, Dillon D, Mason BA, Campbell S. Vaginal color Doppler assessment of uterine artery impedance correlates with immunohistochemical markers of endometrial receptivity required for the implantation of an embryo. Fertil Steril. 1995;63 (1):101-8.

Cacciatore B, Simberg N, Fusaro P, Tiitinen A. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril. 1996;66(1):130-4.

Goswamy RK, Steptoe PC. Doppler ultrasound studies of the uterine artery in spontaneous ovarian cycles. Hum Reprod. 1988;3(6):721-6.

Puerto B, Creus M, Carmona F, Civico S, Vanrell JA, Balasch J. Ultrasonography as a predictor of embryo implantation after in vitro fertilization: A controlled study. Fertil Steril. 2003;79(4):1015-22.

Ng EH, Chan CC, Tang OS, Yeung WS, Ho PC. The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment. Eur J Obstet Gynecol Reprod Biol. 2007;135(1):8-16.

Prasad S, Goyal R, Kumar Y, Nayar P, Hajela S, Kumaran A, Vairagi R, Chauhan S. The relationship between uterine artery two-dimensional color doppler measurement and pregnancy outcome: a prospective observational study. J Reproduct Infertil. 2017;18(2):251.

Guzel AI, Erkılınc S, Ozer I, Tokmak A, Sahin AK, Ugur M. Are uterine and ovarian artery Doppler velocimetry values good pregnancy predictors in clomiphene citrate cycles? Int J Fertil Steril. 2015;9(1):41.

Ivanovski M, Damcevski N, Radevska B, Doicev G. Assessment of uterine artery and arcuate artery blood flow by transvaginal color Doppler ultrasound on the day of human chorionic gonadotropin administration as predictors of pregnancy in an in vitro fertilization program. Akusherstvo I Ginekologiia. 2012;51(2):55-60.

Zollner U, Specketer MT, Zollner KP, Dietl J. Uterine artery blood flow in the periimplantation period in embryo transfer cycles. Asian Pacific J Reproduct. 2012;1(3):177-82.

Engmann L, Sladkevicius P, Agrawal R, Bekir J, Campbell S, Tan SL. The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. Ultrasound in Obstetrics and Gynecology: J Int Soc Ultras Obstet Gynecol. 1999;13(1):26-33.

Adibi A, Khadem M, Mardanian F, Hovsepian S. Uterine and arcuate arteries blood flow for predicting of ongoing pregnancy in in vitro fertilization. Journal of research in medical sciences: Off J Isfahan University of Med Sci. 2015;20(9):879.






Original Research Articles