Comparison of iron carboxy maltose and iron sucrose in pregnant females

Isha Sunil, Prabhjit Kour, Mitali Sharma


Background: Maternal anaemia is a common problem worldwide. The aim of this study is to compare the efficacy and safety of FCM vs iron sucrose for correction of iron deficiency during pregnancy.

Methods: This study was conducted in Swasthya healthcare, Jammu for a period of ten months from Sep 2017 to June 2018. A total of 100 women with Hb 7-9.9g% enrolled. They were divided into two groups of 50 each. Group A were given Iron Carboxy maltose and Group B were given Iron Sucrose. These were compared for their efficacy and safety.

Results: In the present study, the rise in mean hemoglobin at 4 weeks in Group A was 1.79±0.47 and 1.06±0.11 in Group B which was highly significant (p-value<0.0001). Rise in mean serum ferritin level at 4 weeks in Group A was 123.80±16.03 and in Group B was 84.78±10.53. Statistically, this rise was also highly significant (p<0.0001). In present study, adverse reactions were observed in 34% patients in Group A, while in Group B it was observed in 52% patients.

Conclusions: Iron carboxy maltose shows higher rise in hemoglobin and ferritin levels as compared to Iron Sucrose and incidence of adverse effects is also comparatively lower in the former.


Anaemia, Iron carboxy maltose, Iron sucrose

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Kumar KJ, Asha N, Murthy DS, Sujatha MS, Manjunath VG. Maternal anemia in various trimesters and its effect on newborn weight and maturity: an observational study. Int J Prev Med. 2013;4(2):193.

Marahtta R. Study of anaemia in pregnancy and its outcome in Nepal Medical College teaching Hospital, Kathmandu, Nepal. Nepal Med Coll J. 2007;9(4):270-4.

Rani KU, Gupta J, Gupta R, Aggarwal KC. Maternal anaemia and its severity: an independent risk factor for preterm delivery and adverse neonatal outcome. Int J Reprod Contracept Obstet Gynecol. 2014;3(2):325-9.

Batar A, Salvi A, Saini L, Agarwal S, Rajoria L, Mital P. Maternal and perinatal outcome of pregnancy with severe anaemia. Int J Biomed Adv Res. 2015;6(08):611-6.

Auerbach M, Adamson J. How we diagnose and treat iron deficiency anaemia. Am J Hematol. 2016;9(1):31-9.

Gautham KSK. Intravenous iron sucrose. World J Anaemia. 2017;(1):20-2.

Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: a review of its use in iron-deficiency anaemia. Drugs 2009; 69(6):739-56.

Metgud MC, Metgud SB, Bellad MB, Metgud SH. Comparison of efficacy and safety of intravenous ferric carboxymaltose vs iron sucrose in the treatment of antepartum iron deficiency anaemia: a randomized controlled trial. J South Asian Feder Obst Gynae. 2016;8(4):314-8.

Joshi SD, Chikkagowdra S, Kumar V. Comparative study of efficacy and safety of intravenous ferric carboxymaltose versus iron sucrose in treatment of postpartum iron deficiency anaemia. Int J Reprod Contracept Obstet Gynecol. 2016;5(8):2566-70.

Garg R, Nigam A, Agrawal P, Nigam A, Agrawal R. Iron Carboxymaltose: A Safe and Effective Molecule to Combat Anaemia in Pregnancy. Int J Curr Res Aca Rev 2016;4(2):124-30.

Maheshwari B, Mahtab V, Tyagi S, Tyagi P. Evaluation of efficacy, safety and cost effectiveness of oral iron and injectable iron sucrose and ferric carboxy maltose in pregnant women in 2nd and 3rd trimester in anaemia. Ind J Obstet Gynecol Res. 2017;4(1):96-100.

Boughton S, Chen L, Kidson‐Gerber G, Curtain C, Zaidi ST, Henry A. Intravenous iron sucrose and ferric carboxymaltose in pregnant patients: an observational study of maternal efficacy and tolerance. J Pharmacy Pract Res. 2017;47(6):419-25.

Patel J, Patel K, Sharma A, Date SK. Comparison of intravenous Iron sucrose and intravenous Ferric carboxymaltose therapy in iron deficiency anemia during pregnancy and postpartum period. J Pharmac Sci Bioscient Res. 2015;5(3):239-43.