A descriptive study on histopathology of fallopian tube in neoplastic surface epithelial ovarian tumors
Keywords:Epithelial, Histopathology, Ovarian, Tumors
Background: The incidence of cancer is increasing day by day. Ovarian cancer ranks as the fifth leading cause of cancer related death among women worldwide. The cure rate of early stage disease is high. The accepted view is that ovarian cancer arises from ovarian surface epithelium. Recent evidence suggested that around sixty percentage of women without a genetic predisposition who developed sporadic ovarian cancer also have early tubal lesion and cancer. The present study aims to find out the histopathology of fallopian tube in neoplastic surface epithelial ovarian tumour.
Methods: A descriptive study was conducted among hundred women who had undergone surgery for malignant and benign surface epithelial ovarian tumor from Govt. Medical College, Kottayam for one year from January-December 2017.
Results: Fifty percent of the patients had malignant surface epithelial ovarian tumors.
Conclusions: The risk factors of malignant surface epithelial ovarian tumors include age above fifty years and post-menopausal women. Whereas oral contraceptive pill use is a protective factor against malignant surface epithelial ovarian tumors. The fimbrial end of fallopian tube is the site of origin of malignancy in high grade ovarian epithelial carcinoma. So, prophylactic bilateral salpingectomy should be encouraged in all patients who have completed family and undergoing hysterectomy. This will reduce the morbidity and mortality due to ovarian carcinoma.
Piek JM, Dorsman JC, Shvarts A, Ansink AC, Massuger LF, Scholten P, Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma.2004;92(3):819-26.
Shaw PA,Rouzbahman M, Pizer ES, Pintile M, Begley H. Candidate serous cancer precursors in fallopian tube epithelium of BRCA ½ mutation carriers. Mod Pathol. 2009;22(9):1133-8.
Karlan BY, Boyd J, Strong L, Garber J, Fountain J, Beller U. Discussion: hereditary ovarian cancer. Gynecologic Oncol. 2003;88(1):S11-3.
Auner V, Kriegshäuser G, Tong D, Horvat R, Reinthaller A, Mustea A et al. KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. BMC cancer. 2009;9(1):111.
Bell DA, Scully RE. Early de novo ovarian carcinoma. A study of fourteen cases. Cancer.1994;73(7):1859-64.
Bulun SE. Endometriosis.N ENgl J Med. 2009;360(3):268-79.
Callahan MJ, Crum C, Medeiros F et.al. rimary fallopian tube malignancies in BRCA positive women undergoing surgery for ovarian cancer risk reduction. J Clin Oncol. 2007;25(25):3985-90.
Carcangiu ML, Radice P, Manoukian S, Spatti G, Gobbo M, Pensotti V, et.al. Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers. Int J Gynecol Pathol. 2004;23(1):35-40.
Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infedility of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med. 2005;11(5):531-7.
Cho KR, Shih I. Ovarian Cancer. Annu Rev Pathol. 2009;4:287-313.
Colgan TJ, Murphy J, Cole DE, Narod S, Rosen B et al. Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status. Am J Surg Pathol. 2001;25(10):1283-9.
Dehari R, Kurman RJ, Logani S, Shih IM. The development of high- grade serous carcinoma from atypical proliferative(borderline) serous tumora and low grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. Am J Surg Pathol. 2007;31(7):1007-12.
Deligdisch L, Gil J, Kerner H et al. Ovarian dysplasia in prophylactic oophorectomy specimens: cytogenetic and morphometric correlations. Cancer. 1999;86(8):1544-50.
Shuster LT, Gostout BS, Grossardt BR, Rocca WA. Prophylactic oophorectomy in premenopausal women and long-term health. Menopause Int 2008;14(3):111-6.
Cass I, Holschneider C, Datta N, Barbuto D, Walts AE, Karlan BY. BRCA-mutation-associated fallopian tube carcinoma: a distinct clinical phenotype? Obstet Gynecol 2005;106(6):1327-34.
Callahan MJ, Crum CP, Medeiros F, Kindelberger DW, Elvin JA, Garber JE, et al. Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. J Clin Oncol 2007;25(25):3985-90.
Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol 2005;106(2):219-26.
Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol. 2007;31(2):161-910.