Does advanced maternal age influence obstetric outcome: a study in a tertiary care centre
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20190976Keywords:
Advanced maternal age, Close supervision, Frequent antenatal visitAbstract
Background: Advanced maternal age defined as age 35 years and older at estimated date of delivery has become increasingly common in last two to three decades. The International Federation of Gynaecology and Obstetrics in 1958 recommended that all women going through their first pregnancy over the age of 35 years should be considered high risk for pregnancy and included in this category 1.
Methods: A one-year prospective observational study conducted in a tertiary care hospital after institutional ethical clearance. All 165 women above 35yrs who delivered during this period were taken as Cohort 1. Same number of women aged between 20 and 34 years were randomly selected as comparison group (Cohort 2). Both the groups were compared in terms of preexisting medical disorders, obstetrical morbidities, antenatal complications, intrapartum complications.
Results: Older and younger women had similar antenatal booking, occupational and socioeconomic status. The main reason for pregnancy at advanced age group was late marriage. The risk of chronic hypertension, gestational diabetes mellitus, pre-existing medical disorders were higher in advanced maternal age.
Conclusions: Increasing maternal age is associated with elevated risks for pregnancy complications. They are at high risk for gestational diabetes, cesarean section and to have low birth weight babies. Since these women are at higher risk of complications, they should be advised to adhere to frequent antenatal visits and close supervision.
Metrics
References
Maternal age : The mature gravid Kirz DS, Dorchester W, Freeman RK. Advanced Am J Obst Gynecol. 1985;152(1):7-12.
Gilbert WM, Nesbitt TS, Danielsen B. Childbearing beyond age 40: pregnancy outcome in 24,032 cases. Obstet Gynecol. 1999 ;93(1):9-14.
Bobrowski RA, Bottoms SF. Underappreciated risks of the elderly multipara. America J Obstet Gynecol. 1995;172(6):1764-70.
Hook EB, Cross PK, Schreinemachers DM. Chromosomal abnormality rates at amniocentesis and in live-born infants. Jama. 1983 Apr 15;249(15):2034-8.
Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava RP. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012;119(5):890-901.
Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, Saade GR, Eddleman KA, Klugman S, Dugoff L, Timor-Tritsch IE. Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005;105(5):983-90.
Jacobsson B, Ladfors L, Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol. 2004;104(4):727-33.
Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Thorp Jr JM, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW. First-trimester prediction of preeclampsia in low-risk nulliparous women. Obstet Gynecol. 2012;119(6):1234.
Fulop T, Larbi A, Douziech N. Insulin receptor and ageing. PatholBiol (Paris) 2003; 51(10):574-80.
Smith GC, Cordeaux Y, White IR, Pasupathy D, Missfelder-Lobos H, Pell JP et al. The effect of delaying childbirth on primary cesarean section rates. PLoS medicine. 2008;5(7):e144.
Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, Saade GR, Eddleman KA, Klugman S, Dugoff L, Timor-Tritsch IE. Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005;105(5):983-90.
Reddy UM, Laughon SK, Sun L, Troendle J, Willinger M, Zhang J. Prepregnancy risk factors for antepartum stillbirth in the United States. Obstet Gynecol. 2010;116(5):1119.
Geller SE, Cox SM, Callaghan WM, Berg CJ. Morbidity and mortality in pregnancy: laying the groundwork for safe motherhood. Women's health Issues. 2006;16(4):176-88.
Downloads
Published
How to Cite
Issue
Section
