Fatal outcome in acute fatty liver of pregnancy and review of literature

Reena Rani; Asmita M. Rathore; Sangeeta Bhasin

doi:10.18203/2320-1770.ijrcog20190905

Authors

Reena Rani Department of Obstetrics and Gynecology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India
Asmita M. Rathore Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Hospitals, Delhi, India
Sangeeta Bhasin Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Hospitals, Delhi, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20190905

Keywords:

Acute fatty liver, Coagulopathy, Encephalopathy, Pregnancy

Abstract

Acute fatty liver of pregnancy (AFLP) is an uncommon life-threatening disorder of pregnancy seen commonly in third trimester. When not diagnosed at right time it can lead to hepatic failure, encephalopathy, coagulopathy, maternal and fetal mortality. The clinical symptoms and signs are nonspecific, and it needs to be identified early in order to prevent poor outcome. The gold standard for diagnosis of AFLP is liver biopsy, which is difficult in an acute setting and in abnormal coagulation profile hence the diagnosis is usually based on clinical criteria Early termination of pregnancy and good intensive care support are the mainstay of management. The authors here presented a case report where even early delivery and good critical care failed to prevent maternal mortality. Review of literature regarding etiopathogenesis, management and recurrences of AFLP are also discussed.

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Author Biography

Sangeeta Bhasin, Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Hospitals, Delhi, India

CMO(NFSG), Department of Obstetrics and Gynaecology

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