Role of second trimester uterine artery doppler for the prediction of preeclampsia in high risk pregnancy

Authors

  • Madhuri Thakur Department of Obstetrics and Gynecology, Government Medical College and Hospital, Sector 32, Chandigarh, India
  • Reeti Mehra Department of Obstetrics and Gynecology, Government Medical College and Hospital, Sector 32, Chandigarh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20190855

Keywords:

Diastolic notch, Pulsatility index, Resistance index, S/D ratio, Uterine artery Doppler

Abstract

Background: The uterine artery Doppler has potentials for screening for complications of impaired placentation. The purpose of study was to assess the role of uterine artery color Doppler waveform analysis in second trimester for the prediction of preeclampsia in a high-risk pregnancy between 18-24 weeks of gestation.

Methods: 100 women with moderate or high-risk factors for developing preeclampsia reporting to Obstetrics and Gynaecology department of Government Medical College and Hospital, Sector 32, Chandigarh were enrolled for present study. Transabdominal uterine artery doppler measurements was done at 18-24weeks of gestation in these patients. Doppler . The Doppler indices generated automatically from the machine , the Pulsatility Index (PI), Resistance Index (RI) , presence or absence of diastolic notch and S/D Ratio were recorded, and average was calculated.

Results: Out of 100 patients there were 46 primigravidas with no additional risk factors, 22 pateints with two or more risk factors and there were no patients who had three or more risk factors in present study population. Preeclampsia is seen more commonly in primigravida and primigravida is considered as moderate risk factor for preeclampsia. It was found that an elevated second trimester uterine artery RI was significantly associated with developing preeclampsia later in pregnancy. The sensitivity and specificity of uterine artery Doppler velocimetry were found to be 84% and 55% respectively. Receiver operator characteristics (ROC) curves were created to demonstrate the prognostic value of RI and PI of uterine artery doppler indices at 18-24 weeks of gestation for the development preeclampsia. In addition, there were statistically significant positive correlations between mean RI of uterine artery doppler study and patients who developed preeclampsia. With a sensitivity of 84.21% it could identify 31% of the cases of preeclampsia at a false positive rate of 44.4%.

Conclusions: Uterine artery doppler study can be used as a predictor of moderate strength for preeclampsia.

References

Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi J-M. Pre-eclampsia: pathophysiology, diagnosis, and management. Vascul Heal Risk Manage. 2011;7:467-74.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365(9461):785-99.

Askie LM, Duley L, Henderson-Smart DJ, Stewart LA. Antiplatelet agents for prevention of pre-eclampsia: ameta-analysis of individual patient data. Lancet. 2007;369(9575):1791-8.

Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007;(2):CD004659.

Bhattacharyya SK, Kundu S, Kabiraj SP. Prediction of Preeclampsia by Mid-trimester Uterine Artery Doppler velocimetry in high risk and low risk women. J Obstet Gynaecol India. 2012;62(3):297-300.

Papageorghiou AT, Yu CK, Nicolaides KH. The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res. Clin Obstet Gynaecol. 2004;18(3):383-96.

Antsaklis A, Daskalakis G, Tzortzis E, Michalas S. The effect of gestational age and placental location on the prediction of preeclampsia by uterine artery Doppler velocimetry in low-risk nulliparous woman. Ultrasound Obstet Gynecol. 2000;16(7):6359.

Coleman MAG, Mc Cowan LME, North RA. Mid trimester uterine artery Doppler screening as a predictor of adverse pregnancy outcome in high risk women. Ultrasound Obstet Gynecol. 2000;15(1):7-12.

Pongrojpaw D, Chanthasenanont A, Nanthakomon T. Second trimester uterine artery Doppler screening in prediction of adverse pregnancy outcome in high risk women. J Med Assoc Thai. 2010;93(7):S127-30.

Poon LC, Volpe N, Muto B, Yu CK, Syngelaki A, Nicolaides KH. Second-trimester uterine artery Doppler in the prediction of stillbirths. Fetal Diagn Ther. 2013;33(1):28-35.

Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW et al. The Utility of Uterine Artery Doppler Velocimetry in Prediction of Preeclampsia in a Low-Risk Population. Obstet Gynecol. 2012;120(4):815-22.

Downloads

Published

2019-02-26

Issue

Section

Original Research Articles