Published: 2019-03-26

Aetiology of jaundice in pregnancy: observational study in a tertiary care hospital

S. Vinayachandran, Anaswara K.


Background: Jaundice in pregnancy has potentially serious consequences to both mother and foetus. This study aims to find out the aetiology of jaundice and its severity in pregnancy.

Methods: This is an observational prospective study over a period of one and a half years conducted in the Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode. Antenatal patients who presented with jaundice was included in this study.

Results: Out of 24060 deliveries in the study period of one and a half years there were 52 cases of jaundice complicating pregnancy. Incidence of jaundice complicating pregnancy was found to be 0.22%. Largest number of women belonged to the age group 21-25 years of age. Most of the cases occurred in the third trimester. 55.8% of the cases were multigravidas Most common cause of jaundice in pregnancy was found to be HELLP syndrome (34.6%) followed by Hepatitis A (32.7%) 67.3% of the cases had only mild elevation of bilirubin levels (2-5.9mg/dl). 65.4% had an SGOT value of less than 200U/litre and 67.3 % had an SGPT value of less than 200U/litre.

Conclusions: The decrease in the number of cases of viral hepatitis may be due to the increased awareness about the transmission of disease and improvement in sanitary conditions.


HELLP syndrome, Hepatitis A, Jaundice

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Roche SP, Kobos R. Jaundice in the adult patient. Am Fam Phys. 2004;69:299-308.

Oladokun A, Otegbayo JA, Adeniyi AA. Maternal and foetal out comes of jaundice in pregnancy at the University College Hospital, Ibadan. Nigerian J Clin Pract. 2009;12(3).

Acharya N, Acharya S, Shukla S, Athvale R. Study of jaundice in pregnancy. Global J Med Res. 2014.

Reddy MG, Prabhakar GC, Sree V. Maternal and fetal outcome in jaundice complicating pregnancy. J Dr. NTR Univ Health Sci. 2014;3:231.

Tripti N, Sarita A. Fetomaternal outcome in jaundice during pregnancy. J Obstet Gynecol India. 2005;55:424-7.

Sarkar CS, Giri AK. Jaundice in pregnancy: a clinical study. J Indian Med Assoc. 1992;90:117-8.

Krishnamoorthy J, Murugesan A. Jaundice during pregnancy: maternal and foetal outcome. Int J Reprod Contracept Obstet Gynaecol. 2017;5:2541-5.

Suri AD, Jain RK, Jain SC. Study of Jaundice profile in Pregnancy in tertiary care centre in central India. Int J Med Res Rev. 2014;2.

Satia MN, Jandhyala M. A study of fetomaternal outcomes in cases of jaundice at a tertiary care centre. Int J Reprod Contracept Obstet Gynecol. 2017;5:2352-7.

Ambreen A, Ahmed F, Sheikh A, Ayub MR, Faryad N, Mushtaq S. Jaundice in pregnancy: a clinical study at Fatima Memorial System. J South Asian Fed Obstet Gynaecol. 2015;7:22-5.

Shukla S, Mehta G, Jais M, Singh A. A prospective study on acute viral hepatitis in pregnancy; seroprevalence, and fetomaternal outcome of 100 cases. J Biosci Tech. 2011;2:279-86.

Devarbhavi H, Kremers WK, Dierkhising R, Padmanabhan L. Pregnancy-associated acute liver disease and acute viral hepatitis: differentiation, course and outcome. J Hepatol. 2008;49:930-5.

Audibert F, Friedman SA, Frangieh AY, Sibai BM. Clinical utility of strict diagnostic criteria for the HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynaecol. 1996;175:460-4.