A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

Veeraraghavan Gurusamy; Madurai Padmanabhan Kanchana; Lakshmi Narasimhan Srinivasan

doi:10.18203/2320-1770.ijrcog20164353

Authors

Veeraraghavan Gurusamy Department of Pathology, Institute of Obstetrics and Gynecology, Madras Medical College, Chennai, India
Madurai Padmanabhan Kanchana Department of Pathology, Institute of Obstetrics and Gynecology, Madras Medical College, Chennai, India
Lakshmi Narasimhan Srinivasan Department of Medical Oncology, Institute of Obstetrics and Gynecology, Madras Medical College, Chennai, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20164353

Keywords:

Beta hCG, Choriocarcinoma, Chemotherapy, Epithelioid trophoblastic tumour, Gestational trophoblastic disease, Gestational trophoblastic neoplasia

Abstract

Background: The aim of this study is to assess the post diagnostic outcome of Gestational Trophoblastic Disease, a heterogeneous group of disorders, in a government obstetrical tertiary care centre.

Methods: The study was conducted in the Institute of Obstetrics & Gynecology, Madras Medical College as a retrospective study. A total of 75 cases were studied over a 3 year period from January 2012 to December 2015. The parameters which were studied included age group, antecedent pregnancy, beta hCG values, histopathological types and Treatment profile.

Results: Of the 75 cases, 55 cases (73%) were in the 21-39 age group. The spectrum of disorders that were studied included 69 cases of complete mole, 2 cases of partial mole, 1 case of twin pregnancy with single live foetus and partial mole, 1 case of triplet pregnancy with two live foetuses and partial mole, 1 case of epithelioid trophoblastic tumour and 1 case of choriocarcinoma. Of the 75 cases, 16 cases underwent chemotherapy. No mortality was observed during the study period.

Conclusions: Close monitoring and follow up with beta hCG values is of utmost importance in the management of Gestational trophoblastic disease. In cases of gestational trophoblastic neoplasia (GTN), WHO/FIGO scoring should be done and managed with chemotherapy according to the risk assessment.