Effect of eclampsia on pregnancy outcome at tertiary care center, Gujarat, India


  • Nidhi Patel Department of Obstetrics and Gynecology, GMERS Medical College, Ahmedabad, Gujarat, India
  • Sumant Shah Department of Obstetrics and Gynecology, BJ Medical College, Ahmedabad, Gujarat




Eclampsia, Hypertension, Maternal mortality, Third trimester pregnancy


Background: Eclampsia, a common medical emergency of pregnancy mainly seen in 5% to 10% of all pregnancies. The objective of the present study was to study the effect of eclampsia on maternal and perinatal outcome.

Methods: This cross-sectional study was conducted among 50 clinically diagnosed women with eclampsia in their third trimester of pregnancy. Inclusion criteria for the study was; females with singleton pregnancy, all in the third trimester which were diagnosed to have PIH based on the development of hypertension for the first time, proteinuria with or without edema, with no history of previous urinary tract troubles and no evidence of UTI.

Results: Almost 84.0% participants were belonged to age group of 20 to 30 years age, 54.0% were belonged to rural area and 92.0% were belonged to lower socio-economical class, 88.0%% participants were registered as emergency case, 34.0% participants were stayed more than 10 days at hospital and 36.0% were completed ANC visit. Almost 24.0% participants were anemic, 6.0% pre-eclampsic and 4.0% have tween pregnancy. Severe hypertension at the time of admission were noted in 50.0% participants followed by absent knee jerk (12.0%), proteinuria (78.0%) and edema (62.0%) respectively. Maternal mortality and still birth observed in 2.0% and 18.0% cases respectively.

Conclusions: Early age, lower socio-economic class, anemia, less ANC clinic visit, higher hospital stay and primigravida observed more among study participants and these factors may play an important role in the pathogenesis of eclampsia.


Malas NO, Shurideh ZM. Does serum calcium in pre-eclampsia and normal pregnancy differ? Saudi Med J. 2001;22(10):868-71.

Purohit A, Vyas RK, Sharma ML, Soni Y, Verma A. Serum magnesium status in preeclampsia. Int J Med Sci Education. 2016;3(1):1-8.

Omu AE, Al-Harmi J, Vedi HL, Mlechkova L, Sayed AF, Al-Ragum NS. Magnesium Sulphate Therapy in Women with Pre-Eclampsia and Eclampsia in Kuwait. Med Princ Pract. 2008;17(3):227-32.

Singh A, Verma AK, Hassan G, Prakash V, Sharma P. Serum magnesium levels in patients with pre-eclampsia and eclampsia with different regimens of magnesium sulphate. GJMEDPH 2013;2(1):1-9.

Cunningham FG, Pritchard JA. How should hypertension during pregnancy be managed? Experience at Parkland Memorial Hospital. Medic Clinics North Am. 1984;68(2):505-26.

Tomlinson TM, Sadovsky Y. Pregnancy: preeclampsia and eclampsia. In: Kollef MH,Bedient TJ, Isakow W, Witt CA. The Washington Manual of Critical Care, 8thed.NewYork : Wolters-Lippincott Williams and Wilkins 2010.439-445.

Duley L: Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America, Caribbean. Br J Obtet Gynaecol,1992;99(7):547-53.

Siabai B. Prevention of preeclampsia: a big disappointment. Am J Obstet Gynaecol. 1998;179(5):1275-8.

Hojo M, August P. Magnesium metabolism in preeclampsia: supplementation may help. Medscape Women Health. 1997;2(1):5.

Marcoux S, Berube S, Brisson C, Mondor M. Job Strain and pregnancy induced hypertension. Epidemiol. 1999;10:376-82.

Pairu J, Triveni GS, Manohar A. The study of serum calcium and serum magnesium in pregnancy induced hypertension and normal pregnancy. Int J Reprod Contracep Obstet Gynecol. 2015;4(1):30-4.

Tong GM, Rude RK. Magnesium deficiency in critical illness. J Intensive Care Med. 2005;20(1):3-17.

Touy ZRM. Role of magnesium deficiency in pathogenesis of hypertension. Mol Aspects Med. 2003;24(10):107-36.

Kisters K, Barenbroka M, Louwenb F, Hausberga M, Rahna KH, Koscha M. Membrane, intracellular and plasma magnesium, and calcium concentrations in preeclampsia. Am J Hypertens. 2000;13(7):765-9.

Tavana Z, Hosseinmirzaei S. Comparison of Maternal Serum Magnesium Level in Pre-eclampsia and Normal Pregnant Women. Iran Red Cres Med J. 2013;15(12):e10394.

Darkwa EO, Charles AB, Robert D, Owooo C. Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana. Integ Blood Press Cont 2017;10:9-15.

Kumar R, Gandhi S, Rao V. Socio-Demographic and Other Risk Factors of Pre-Eclampsia at a Tertiary Care Hospital, Karnataka: Case Control Study. J Clinic Diagnos Research.2014;8(9):1-4.

Duckitt K, Harrington D. Risk factors for preeclampsia at antenatal booking: systematic review of controlled studies. BMJ.2005;330(7491):565-77.

Silva LM, Coolman M, Steegers EA, Jaddoe VW, Moll HA, Hofman A. Low socioeconomic status is a risk factor for preeclampsia: The Generation R Study. J Hypertens. 2008;26(6):1200-8.

Sandhu G, Ramaiyah S, Chan G, Meisels I. Pathophysiology and Management of Preeclampsia-Associated Severe Hyponatremia. AJKD 2010;55(3):599-603.

Gaddi suman,Somegowdel : maternal and perinatal outcome in Eclampsia in district hospital; VIMS, Bellary. J Obstet Gynecol India 2007/57(4):324-6.

Maray P, Emin U, Omer LT, Tuncay G. Factors influencing the postpartum length of hospital stay in eclamptic women. Taiwan J Obstet Gynecol. 2007;46(4):410-3.

English FA, Kenny LC, Mccarthy FP. Risk factors and effective management of preeclampsia. Integ Blood Pressure Cont 2015;8:7-12.

Ali et al.: Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan. BMC Res Notes. 2011;4(1):311.

Barden AE, Beilin LJ, Ritchie J, Barry NW. Is proteinuric pre-eclampsia a different disease in primigravida and multigravida? Clinical Sci 1999;97(4):475-483.






Original Research Articles