Study of placental location and pregnancy outcome


  • Vidhu V. Nair Department of Obstetrics and Gynecology, Amrita Institute of Medical Sciences, Amrita Viswavidyapeetham University, Kochi, Kerala, India
  • Sobha S. Nair Department of Obstetrics and Gynecology, Amrita Institute of Medical Sciences, Amrita Viswavidyapeetham University, Kochi, Kerala, India
  • Radhamany K. Department of Obstetrics and Gynecology, Amrita Institute of Medical Sciences, Amrita Viswavidyapeetham University, Kochi, Kerala, India



Abnormal outcome, Lateral placenta, Neonatal outcome, Placental location, Pregnancy outcome


Background: Placental location can be estimated easily using ultrasonogram by 16 weeks. It can be classified based on its location into central and lateral. Central can be anterior or posterior. Lateral can be left lateral or right lateral. Placental location has been attributed to both normal and abnormal pregnancy and neonatal outcomes.

Methods: This is a prospective cohort study conducted in the department of Obstetrics and Gynecology which comprised of 450 singleton gestations between 18 and 24 weeks. The primary objective is to determine the association between placental location and pregnancy outcome and secondary objective is to find out the association between placental location and neonatal outcome. The study population was divided into two groups – central and lateral. Results were analyzed using SPSS version 20, Chi square test and independent two sample t-test.

Results: The frequency of central placenta was 377 (83.8%) and lateral placenta in 73 (16.2%). Central placentation had an abnormal outcome in 182(48.3%), lateral placentas with abnormal outcome were 44(60.3%). Abnormal maternal outcomes like hypertensive disorders (33.3%), Intra Uterine Growth Restriction (10.2%), Antepartum haemorrhage (25%), Preterm birth (16.3%) were more in lateral placentation. The number of central placentas having NICU admissions were 62(16.4%) and lateral placenta with NICU admissions were 19(26%).

Conclusions: There is a significant association between lateral placentation and abnormal pregnancy and neonatal outcomes. Second trimester ultrasound can be used as non-invasive predictor of adverse pregnancy and neonatal outcomes.



Olive EC, Roberts CL, Nassar N, Algert CS. Test characteristics of placental location screening by transabdominal ultrasound at 18-20 weeks. Ultrasound Obstet Gynecol. 2006;28(7):944-9.

Benirschke K, Burton GJ, Baergen RN. Early development of the human placenta. InPathology of the human placenta 2012 Springer, Berlin, Heidelberg. PP 41-53.

Magann EF, Doherty DA, Turner K, Lanneau GS, Morrison JC, Newnham JP. Second trimester placental location as a predictor of an adverse pregnancy outcome. J Perinatol. 2007;27(1):9-14.

Warland J, McCutcheon H, Baghurst P. Placental position and late stillbirth: a case-control study. J Clin Nurs. 2009;18(11):1602-6.

Singh N, Gupta R, Pandey K, Gupta N, Chandanan A, Singh P. To study second trimester placental location as a predictor of adverse pregnancy outcome. Int J Reproduct, Contracep, Obstet Gynecol. 2016;6(6):1414-7.

Jaiswal J, Jaiswal A, Nagaria T, Ramteke A. Placental laterality, Preeclampsia, PIH, Ghtn. Prediction of pregnancy induced hypertension by USG guided placental localization. 2015;10(9185).

Jaisal P, Bhonsale D. Association of Placental Localization at 16-24 Week and Pregnancy Outcome. Int J Med Res Prof. 2016;2(4):7-9.

Devarajan K, Kives S, Ray JG. Placental location and newborn weight. J Obstet Gynaecol Can. 2012;34(4):325-9.

Sekiguchi A, Nakai A, Kawabata I, Hayashi M, Takeshita T. Type and Location of Placenta Previa Affect Preterm Delivery Risk Related to Antepartum Hemorrhage. Int J Med Sci. 2013;10(12):1683-8.

Zia S. Placental location and pregnancy outcome. J Turk Ger Gynecol Assoc. 2013;14(4):190-3.

Nandanwar RA, Wahane AM, Dange NS. The Relation between development of Pregnancy Induced Hypertension and location of placenta among the pregnant women in Bastar Region. Indian J Clinic Anat Physiol. 2015;2(4):169.

Bhalerao AV, Kukarni S, Somalwar S. Lateral placentation by ultasonography: a simple predictor of preeclampsia. J South Asian Feder Obst Gynae. 2013;5(2):68-71.

Jang DG, We JS, Shin JU, Choi YJ, Ko HS, Park IY, et al. Maternal outcomes according to placental position in placental previa. Int J Med Sci. 2011;8(5):439-44.

Pai MV, Pillai J. Placental laterality by ultrasound–a simple yet reliable predictive test for preeclampsia. J Obstet Gynecol India. 2005;55(5):431-3.

Fung TY, Sahota DS, Lau TK, Leung TY, Chan LW, Chung TKH. Placental site in the second trimester of pregnancy and its association with subsequent obstetric outcome. Prenat Diagn. 2011;31(6):548-54.

Kakkar T, Singh V, Razdan R, Digra SK, Gupta A, Kakkar M. Placental Laterality as a Predictor for Development of Preeclampsia. J Obstet Gynaecol India. 2013;63(1):22-5.

Gizzo S, Noventa M, Vitagliano A, Quaranta M, Giovanni VD, Borgato S, et al. Sonographic assessment of placental location: a mere notional description or an important key to improve both pregnancy and perinatal obstetrical care? A large cohort study. Int J Clin Exp Med. 2015;8(8):13056-66.

Kalanithi LEG, Illuzzi JL, Nossov VB, Frisbaek Y, Abdel-Razeq S, Copel JA, et al. Intrauterine growth restriction and placental location. J Ultrasound Med. 2007;26(11):1481-9.

Seadati N, Najafian M, Cheraghi M, Mohammadi B. Placental location at second trimester and pregnancy outcomes. J Pharm Sci Innov. 2013;2(2):32-4.

Jackson R, Carson M, Melamed N, Barrett JF, Mei-Dan E. 469: The impact of placental location on neonatal adverse outcomes. Am J Obstet Gynecol. 2018;218(1):S282.

Torricelli M, Vannuccini S, Moncini I, Cannoni A, Voltolini C, Conti N, et al. Anterior placental location influences onset and progress of labor and postpartum outcome. Placenta. 2015;36(4):463-6.






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