Association of hyperlipidaemia in preterm delivery


  • Ruthvika Kundoor Department of Obstetrics and Gynecology, Osmania University, Hyderabad, Telangana, India
  • Burri Sandhya Rani Department of Obstetrics and Gynecology, Laxmi Narasimha Hospital, Hanumakonda, Warangal, Telangana, India



Cholesterol, Preterm Labour, Hyperlipidemia


Background: Premature infant is the most important outcome of preterm delivery and is also the cause for infant mortality after congenital abnormality. Around the world, there are 3.6 million per year neonatal deaths, of which in developing countries, 99% deaths are observed. This study was conducted to evaluate the elevated triglycerides and cholesterol relationship on preterm labor risk.

Methods: 350 healthy pregnant women were included in the study group in the age group of 18-36 years, their gestational age was confirmed either by last menstrual period or by ultrasound. This study was conducted in Department of Obstetrics  and Gynaecology at Osmania University, Hyderabad, Telangana India.

Results: The good outcomes were observed in mothers with normal cholesterol values and preterm deliveries were observed in 32.14% of mothers with abnormal cholesterol values. 0.3% of mothers with normal triglyceride values and 75% of mothers with abnormal values had preterm delivery. P value difference was statistically significant (P<0.05).

Conclusions: By measuring serum total cholesterol and triglycerides, along with serum screening of α-fetoprotein and inhibin A, it can be used to predict the preterm labour.


Rafael TJ, Hoffman MK, Leiby BE, Berghella V. Gestational age of previous twin preterm birth as a predictor for subsequent singleton preterm birth. Am J Obstet Gynecol. 2012;206(2):156-e1.

Butler AS, Behrman RE, editors. Preterm birth: causes, consequences, and prevention. National Academies Press; 2007.

Lawn JE, Kerber K, Enweronu-Laryea C, Cousens S.3.6 million neonatal deaths - what is progressing and what is not? Semin Perinatol. 2010;34(6):371-86.

Herrera E, Amusquivar E, Lopez-Soldado I, Ortega H. Maternal lipid metabolism and placental lipid transfer. Horm Res. 2006;65(3):59-64.

Martin U, Davies C, Hayavi S, Hartland A, Dunne F. Is normal pregnancy atherogenic? Clin Sci. 1999;96(4):421-5.

Kramer MS, Kahn SR, Rozen R, Evans R, Platt RW, Chen MF, et al. Vasculopathic and thrombophilic risk factors for spontaneous preterm birth. Int J Epidemiol. 2009;38(3):715-23.

Alleman BW, Smith AR, Byers HM, Bedell B, Ryckman KK, Murray JC, et al. A proposed method to predict preterm birth using clinical data, standard maternal serum screening, and cholesterol. Am J Obstet Gynecol. 2013;208(6):472.e1-11.

Catov JM, Bodnar LM, Kip KE, Hubel C, Ness RB, Harger G, et al. Early pregnancy lipid concentrations and spontaneous preterm birth. Am J Obstet Gynecol. 2007;197(6):610.e1-7.

Amundsen AL, Khoury J, Iversen PO, Bergei C, Ose L, Tonstad S, et al. Marked changes in plasma lipids and lipoproteins during pregnancy in women with familial hypercholesterolemia. Atheroscler. 2006;189(2):451-7.

Sowmiya S, Hiremath PB, Kousalya M. Association of hyperlipidemia in preterm delivery. Int J Reprod Contracept Obstet Gynecol. 2015;4(4):972-6.






Original Research Articles