Published: 2019-04-29

A rare case of McCune Albright syndrome

Pooja Patil, Siftie-Kaur Banga


McCune Albright syndrome is characterized by the clinical triad of precocious puberty, polyostotic fibrous dysplasia, and café-au-lait pigmentation. Authors reported the case of a 6 years old girl presenting with vaginal bleeding. Investigations showed high serum oestrogen levels, with low FSH and LH levels. Ultrasonography revealed a multiloculated right ovarian cyst. Based on the history and investigations, the patient was diagnosed as a case of precocious puberty. In order to rule out the presence of any ovarian malignancy, tumour markers were sent and found to be within the normal range. A CT pelvis was done which revealed fibrous dysplasia of the pelvic bone. The coexistence of precocious puberty with fibrous dysplasia confirmed the diagnosis of McCune Albright syndrome.


McCune Albright, Precocious puberty

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Xi Wang, Qi Yu. Management of precocious puberty in girls with McCune-Albright syndrome using letrozole. Endocr Connect. 2018;7(12):1424-31.

Corica D, Aversa T, Pepe G, De Luca F, Wasniewska M. Peculiarities of precocious puberty in boys and girls with McCune-Albright syndrome. Front Endocrinol (Lausanne). 2018;9:337.

Utriainen P. Polyostotic fibrous dysplasia with and without McCune-Albright syndrome-clinical features in a nordic pediatric cohort. Front Endocrinol (Lausanne). 2018;9:96.

Sawathiparnich P, Osuwanaratana P, Santiprabhob, J, Likitmaskui S. Tamoxifen improved final height prediction in a girl with McCune-Albright Syndrome: patient report and literature review. J Pediatr Endocrinol Metab. 2006;19(1):81-6.

Kumar P, Malhotra N. Jeffcoate’s Principles of Gynaecology. Seventh Edition. New Delhi. Jaypee Brother’s Medical Publishers (P) Ltd. 2008.

Hoffman B, Schorge J, Schaffer J, Halvorson L, Bradshaw K, Cunningham F. Williams Gynecology. Second Edition. New York. McGraw Hill Medical. 2012.

Dumitrescu C, Collins M. McCune-Albright syndrome. Orphanet J Rare Dis. 2008;3:12.

Medina YN, Rapaport R. Evolving diagnosis of McCune-Albright syndrome, atypical presentation and follow up. J Pediatr Endocrinol Metab. 2009;22(4):373-7.

Feuillan P, Calis K, Hill S, Shawker T, Robey P, Collins M. Letrozole treatment of precocious puberty in girls with McCune-Albright syndrome: a pilot study. J Clin Endocrinol Metab. 2007;92(6):2100-6.

Schoelwer M, Eugster E. Treatment of peripheral precocious puberty. Endocr Dev. 2016;29:230-9.