Thyroid dysfunction in women with polycystic ovarian syndrome: a comparative study


  • Kshama V. Kedar Department of Obstetrics and Gynecology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Monali M. Rewatkar Department of Biochemistry, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Monika D. Akare Department of Obstetrics and Gynecology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India



Hypothyroidism, Polycystic ovary syndrome, Obesity


Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women. Some of the PCOS women show presence of hypothyroidism.

Methods: This study was conducted at tertiary care centre Indira Gandhi Government Medical College and Hospital (IGGMC), Nagpur, Maharashtra, India. The study group had 50 diagnosed patients of PCOS and 50 age matched normal regular menstruating women were taken as controls.

Results: In this study, PCOS patients showed higher mean TSH level than control group (4.024±1.09 and 2.84±0.83 respectively). And more women were diagnosed with overt hypothyroidism in the PCOS group (6%) than in the control group (2%).

Conclusions: The findings of the study showed that PCOS is associated with hypothyroidism as compared to normal population.


Mueller A, Schofl C, Dittrich R. Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome. Human Repro. 2009;24(11):2924-30.

Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Rev. 1997;18(6):774-800.

Erel CT, Senturk LM, Kaleli S, Gezer A, Baysal B, Tasan E. Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in poly cystic ovary syndrome? Gynecol Endocrinol. 2003;17(3):222-3.

Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Ind J Endocrinol Metab. 2013;17(1):138-45.

Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN, Pal SK. Thyroid disorders in polycystic ovarian syndrome subjects: a tertiary hospital based cross-sectional study from Eastern India. Ind J Endocrinol Metab. 2013;17(2):304-9.

Qun Yu, Jin-BeiWang. Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance and Cardiovascular Risk. BioMed Res Int. 2016(3):1-7.

Singla R, Gupta Y, Khemani M, Aggarwal S. Thyroid disorders and polycystic ovary syndrome: an emerging relationship. Ind J Endocrinol Metab. 2015;19(1):25-9.

Sowmya D, Anitha S. Clinical study of polycystic ovarian syndrome (PCOS) in tertiary care centre. Int J Repro Contracept Obstet Gynecol. 2017;6:3247-51.

Fatma Al-zaroug Elslimani, Mona Elhasi, and Maraia Farag Elmhdwi. The Relation between Hypothyroidism and Polycystic Ovary Syndrome. J. Pharm. Appl. Chem. 2016;2(3):197-200.






Original Research Articles