Placental location and development of preeclampsia: a longitudinal study

Authors

  • Ananya Priyadarshini Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Science, Dehradun, Uttarakhand, India
  • Purnima Upreti Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Science, Dehradun, Uttarakhand, India
  • Ruchira Nautiyal Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Science, Dehradun, Uttarakhand, India
  • Mamta Goyal Department of Radiology, Himalayan Institute of Medical Science, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20191005

Keywords:

Location of placenta, Morbidity, Mortality, Preeclampsia

Abstract

Background: Preeclampsia is one of the leading causes of morbidity and mortality worldwide. A number of pregnant women suffer from it after 20 weeks of their pregnancy. The study was designed to know the association between location of placenta and the development of preeclampsia in pregnant women. the purpose of the study is to determine the incidence of lateral location of placenta and to study the relation between placental location and development of preeclampsia.

Methods: A prospective study conducted on pregnant women who attended the antenatal clinic of SRHU Hospital over period of 12 months. The study was hospital based longitudinal study with a sample size of 100 cases presenting over a period of 12 months in Obstetrics and Gynecology Department. Simple Random Sampling was used for random selection of antenatal case at 18 to 24 weeks gestation with singleton pregnancy, after taking written consent and agreeing for follow-up till delivery.

Results: Out of the total 100 cases taken for the study, there were 68 cases of lateral placenta and 32 cases of central placenta. Most of the cases belonged to middle class living in urban areas. The development of preeclampsia is mainly due to mineral deficiency and high systolic BP.

Conclusions: In present study, 48.5% patients with lateral placenta and 46.9% with central placenta developed pre-eclampsia.  There was a significant association that was found between laterality of placenta and development of PIH. The laterally located placenta is associated with increased risk of developing preeclampsia. Therefore, looking for placental laterality at the time of a mandatory antenatal ultrasound scanning (level II) may serve as a non-invasive test to predict pre-eclampsia.

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References

Sibai BM, Ramadan MK, Usha I. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol. 1993;169:1000-6.

Schroeder BM. ACOG Practice Bulletin on diagnosis and management of pre-eclampsia/ eclampsia. Am J Obstet Gynecol. Am Fam Physician. 2002;66(2):330-1.

Kenny L, English F, McCarthy F. Risk factors and effective management of preeclampsia. Integrated Blood Pressure Control. 2015;8:7.

Maternal mortality. Who.int. 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/maternal-mortality

Powe C, Levine R, Karumanchi S. Preeclampsia, a disease of the maternal endothelium. Circulation. 2011;123(24):2856-69.

Filipov E, Borisov I, Kolarov G. Placental location and its influence on the position of the fetus in the uterus. Akush Ginekol (Sofiia). 2000;40(4):11-2.

Patel D, Dabhadka D, Taralekar D, Wagh D. Placental laterality and uterine artery resistance for prediction of preeclampsia. Indian J Appl Res. 2011;2(2):118-9.

Kakkar T, Singh V, Razdan R, Digra S, Gupta A, Kakkar M. Placental laterality as a predictor for development of preeclampsia. J Obstet Gynecol India. 2012;63(1):22-5.

Das R, Biswas S. Eclapmsia: The major cause of maternal mortality in eastern India. Ethiopian J Health Sci. 2015;25(2):111.

Gilbert J, Nijland M, Knoblich P. Placental ischemia and cardiovascular dysfunction in preeclampsia and beyond: making the connections. Expert Review of Cardiovascular Therapy. 2008;6(10):1367-1377.

Springer.com. (2018). Handbook of Growth and Growth Monitoring in Health and Disease. Victor R. Preedy Springer. Available at: https://www.springer.com/us/book/9781441917942.

Vaillant P, Best MC, Cynober E, Devulder G. Pathological uterine readings when the placenta is laterally situated. J Gynecol Obstet Biol Reprod. 1993;22:301-7.

Barrett H, Callaway L. Hypertensive disorders of pregnancy. BMJ. 2017:3245.

Kofinas A, Penry M, Swain M, Hatjis C. Effect of placental laterality on uterine artery resistance and development of preeclampsia and intrauterine growth retardation. Int J Gynecol Obstet. 1990;32(4):392.

Schulman H, Winter D, Farmakides G, Ducey J, Guzman E, Coury A, et al. Pregnancy surveillance with Doppler velocimetry of uterine and umbilical arteries. Am J Obstet Gynecol. 1989;160(1):192-6.

Ito Y, Shono H, Shono M, Muro M, Uchiyama A, Sugimori H. Resistance index of uterine artery and placental location in intrauterine growth retardation. Acta Obstet Gynecol Scand. 1998;77:385-90.

Nanthini D, Kumari L, Felix AJW. The study of placental latralityand development of pre eclampsia. Int J Modern Research Reviews. 2015;9(3):781-3.

Kakkar T, Singh V. Placental laterality as a predictor for development of preeclampsia. J Obstet Gynecol India. 2013;63(1):22-5.

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Published

2019-03-26

How to Cite

Priyadarshini, A., Upreti, P., Nautiyal, R., & Goyal, M. (2019). Placental location and development of preeclampsia: a longitudinal study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 8(4), 1283–1287. https://doi.org/10.18203/2320-1770.ijrcog20191005

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Original Research Articles