Serum magnesium level in eclampsia at tertiary care center, Gujarat, India

Nidhi Patel, Nilesh Shah


Background: Magnesium may be physiologically important in blood pressure regulation whereas changes in magnesium levels could contribute to the patho-etiology of hypertension. The objective of the present study was to study the level and effect of magnesium in eclamptic pregnant women.

Methods: This cross-sectional study was conducted among 50 clinically diagnosed women with eclampsia in their third trimester of pregnancy. Inclusion criteria for the study was; females with singleton pregnancy, all in the third trimester which were diagnosed to have PIH based on the development of hypertension for the first time, proteinuria with or without edema, with no history of previous urinary tract troubles and no evidence of UTI. The concentration of total serum magnesium was measured by atomic absorption spectroscopy.

Results: Mean age, mean gestational age, mean total hospital stays, mean BMI, mean systolic BP and diastolic BP was 24.3 years with 5.1 SD, 36.4 week with 3.3 SD, 7.8 days with 2.4 SD, 28.9 wt/ht2 with 4.8 SD, 146.5 mmHg with 14.7 SD and 95.9 mmHg with 11.2 SD respectively. Mean magnesium level was 1.9 mmol/L with 2.2 SD.

Conclusions: Hypomagnesemia is present in eclamptic pregnant women. In developing countries like India, sufficient dietary supplementation should be given above the recommended dietary allowances in pregnancy at least in susceptible pregnant women.


Eclampsia, Hypertension, Hypomagnesemia, Magnesium

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Purohit A, Vyas RK, Sharma ML, Soni Y, Verma A. Serum magnesium status in preeclampsia. Int J Med Sci and Edu 2016;3(1):1-6.

Malas NO, Shurideh ZM. Does serum calcium in pre-eclampsia and normal pregnancy differ? Saudi Med J. 2001;22(10):868-871.

Chaudhary RK, Niraula A, Bataju M, Baranwal KJ, Khan SA, Bhatt RD. Serum Calcium and Magnesium levels in Pre-eclampsia. National Journal of Laboratory Medicine. 2018;7(4):BO01-6.

DC Dutta, H Konar, In: DC Dutta’s Textbook of Obstetrics, edited by H Konar, 8th Edition , (JAYPEE The Health Service Publisher, New Delhi, 2013), pp. 219-240.

The World Health Report 2005. Make Every Mother and Child Count, Geneva.2005.

Darkwa EO, Antwi-Boasiako C, Djagbletey R, Owoo C, Obed S, Sottie D. Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana. Integrated Blood Pressure Cont. 2017;10:9-15.

Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367(9516):1066-74.

Cunningham FG, Pritchard JA. How should hypertension during pregnancy be managed? Experience at Parkland Memorial Hospital. The medical clinics of North America. 1984;68(2):505-26.

Tomlinson TM, Sadovsky Y. Pregnancy: preeclampsia and eclampsia. In: Kollef MH, Bedient TJ, Isakow W, Witt CA, editors. The Washington Manual of Critical Care, 8th ed. NewYork : Wolters-Lippincott Williams and Wilkins 2010.439-445.

Duley L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. BJOG: Int J Obstet Gynaecol. 1992;99(7):547-53.

Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular, and plasma magnesium and calcium concentrations in preeclampsia. American J Hypertens. 2000 ;13(7):765-9.

Mazur A, Maier JAM, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys. 2007;458(1):48-56.

Laires MJ, Monterio CP, Bicho M. Role of cellular magnesium in health and human disease. Frontiers Biosci. 2004;9(1):262-76.

Fernandez FJ, Kahn HL. Clinical method for atomic absorption spectroscopy. Clin Chem Newsl. 1971;3:24-8.

Shamsi U, Hatcher J, Shamsi A, Zuberi N, Qadri Z, Saleem S. A multicentre matched case control study of risk factors for Preeclampsia in healthy women in Pakistan. BMC Women's Health 2010;10(1):14.

Tavana Z, Hosseinmirzaei S. Comparison of Maternal Serum Magnesium Level in Pre-eclampsia and Normal Pregnant Women. Iran Red Cres Med J. 2013;15(12):e10394.

Ganesh KS, Unnikrishnan B, Nagraj K, Jayaram S. Determinants of Pre-eclampsia: A Case–control Study in a District Hospital in South India. Indian J Community Med. 2010; 35(4):502-5.

Macdonald-Wallis C, Lawlor DA, Heron J, Fraser A, Nelson SM. Relationships of Risk Factors for Pre-Eclampsia with Patterns of Occurrence of Isolated Gestational Proteinuria during Normal Term Pregnancy. PLoS ONE 2011;6(7): e22115.

Singh A, Verma AK, Hassan G, Prakash V, Sharma P. Serum magnesium levels in patients with pre-eclampsia and eclampsia with different regimens of magnesium sulphate. GJMEDPH 2013;2(1):1-9.

Kumar R, Gandhi S, Rao V. Socio-Demographic and Other Risk Factors of Pre-Eclampsia at a Tertiary Care Hospital, Karnataka: Case Control Study. J Clinic Diagnos Res.2014;8(9):1-4.

Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330(7491):565.

Mostello D, Kallogjeri D, Tungsiripat R, Leet T. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol. 2008;199(1):55.e1-7.

Sohlberg S, Stephansson O, Cnattingius S, Wikström AK. Maternal body mass index, height, and risks of preeclampsia. Am J Hypertens. 2012;25(1):120-5.

Poorolajal J, Jenabi E. The association between body mass index and preeclampsia: a meta-analysis. J Matern Fetal Neonatal Med. 2016;29(22):3670-6.

Mrema D, Lie RT, Østbye T, Mahande MJ, Daltveit AK. The association between pre pregnancy body mass index and risk of preeclampsia: a registry-based study from Tanzania. BMC pregnancy and Childbirth. 2018;18(1):56.

Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Pre pregnancy weight and the risk of adverse pregnancy outcomes. N Eng J Med.1998;338(3):147-52.

Thadhani R, Stampfer MJ, Hunter DJ, Manson JE, Solomon CG, Curhan GC. High body mass index and hypercholesterolemia: risk of hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94(4):543-50.

Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, et al. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metabol Disord: J Int Assoc Study Obes. 2001;25(8):1175-82.

Bodnar LM, Ness RB, Markovic N, Roberts JM. The risk of preeclampsia rises with increasing pre pregnancy body mass index. Ann Epidemiol. 2005;15(7):475-82.

Bhattacharya S, Campbell DM, Liston WA, Bhattacharya S. Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health. 2007;7(1):168.

Kanagal DV, Rajesh A, Rao K, Harshini DU, Shetty H, Kumari S et al. Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India. J Clin Diagn Res. 2014; 8(7):OC01-OC04.

Ephraim RK, Osakunor DN, Denkyira SW, Eshun H, Amoah S, Anto EO. Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana. BMC Pregnancy Childbirth. 2014;14(1):390.

Vafaei H, Dalili M, Hashemi SA. Serum concentration of calcium, magnesium and zinc in normotensive versus preeclampsia pregnant women: A descriptive study in women of Kerman province of Iran. Iran J Reprod Med. 2015;13(1):23-6.

Pairu J, Triveni GS, Manohar A. The study of serum calcium and serum magnesium in pregnancy induced hypertension and normal pregnancy. Int J Reprod Contracept Obstet Gynecol. 2015;4(1):30-34.

Abdellah A, Abdrabo AA. Assessment of serum calcium, magnesium, copper and zinc levels in Sudanese pregnant women with pre- eclampsia. Glo Adv Res J Med Med Sci. 2014;3(2):033-6.

Ibraheem NJ, Obiade DS. Serum calcium level and some physiological markers during Pre-eclampsia and normal pregnancy in Babylon province women. Al-Kufa J Biol. 2013;5(2):1-11.

Akhtar S, Begum S, Ferdousi S. Calcium and Zinc Defiiency in Preeclamptic Women. J Bang Soc Physiol. 2011;6(2):94-9.