Study of thyroid dysfunction in perimenopausal women with abnormal uterine bleeding


  • Velicheti Satya Sree Department of Obstetrics and Gynecology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India
  • Gomathy E. Department of Obstetrics and Gynecology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India



Abnormal uterine bleeding, Perimenopausal, Thyroid disorders


Background: AUB is a common but complicated clinical presentation and occurs in 15-20% of women between menarche to menopause and significantly affects the women’s health. Women with thyroid dysfunction often have menstrual irregularities, infertility and increased morbidity during pregnancy. The objective of present study is to find the correlation between thyroid disorders and AUB in perimenopausal women attending gynecology OPD.

Methods: In the present study, Ninety patients with AUB were included and were evaluated for the cause including thyroid abnormality. Thyroid function tests were done in all patients.

Results: Among 90 patients, 22 patients were diagnosed as hypothyroidism and 9 as hyperthyroidism, women with AUB 59 (65.4%) were euthyroid. Among 31 women with thyroid abnormality, heavy menstrual bleeding was seen in 14 (45.1%) women, 11 (35.4%) had Polymenorrhagia, 6 (19.3%) had oligomenorrhea. The frequent menstrual abnormality in women with hypothyroidism (22 women) was heavy menstrual bleeding in 9 (40.9%) women, 5 (22.7%) had oligomenorrhea, 8 (36.3%) had Polymenorrhagia. Out of 9 women with hyperthyroidism, 3 (33.3%) had oligomenorrhoea, 4 (44.4%) had heavy menstrual bleeding, 2 (22.2%) had Polymenorrhagia.

Conclusions: AUB might be because of structural or non-structural causes. Thyroid abnormalities may present in perimenopausal women with abnormal uterine bleeding, therefore proper identification of the cause of AUB is needed to give appropriate treatment to the patient. And to avoid unnecessary surgical intervention.


Speroff L, Glass RH, Kass NG. In: Clinical Gynaecolog Endocrinilogy and infertility. 9th ed. Baltimore: Lippincott Williams and Wilkins. 2017;201-238:575-9.

Lumsden M, Normal J. Menstruation and Menstrual abnormality. Shaw RW, Soutter WP, Stanton SL (eds) Gynecology, 2nd Edn.

Thomas R, Reid RL. Thyroid diseases and reproductive dysfunction. Obstet Gynaecol. 1987;70:789-98.

Abers JR, Hull SK, Wesley RM. AUB. Am Fam Phy. 2004;68(8):1915-34.

Kaur T, Aseeja V, Sharma S. Thyroid dysfunction in dysfunctional uterine bleeding. Webmed Central Obstet Gynaecol. 2011;2(9):WMC002235.

Longcope C, Abend S, Braverman LE, Emerson CH. Androstenedione and estrone dynamics in hypothyroid women. J Clin Endocrinol Metabol. 1990;70:903-7.

Vinita S, Ashwini SN. Impact of thyroid disorders on menstrual function. Fogsi Focus. 2006;1:30-1.

Singh L, Agarwal CG, Chowdhary SR, Mehra P, Khare R. Thyroid profile in infertile women. J Obst Gyn India. 1990;40:248.

Komathi R, Mallika A, Shantha. A study of thyroid profile in abnormal uterine bleeding (aub) among Reproductive age group women. Int J Current Med Sci. 2016;6:133-6.

Pahwa S, Shailja G, Jasmine K. Thyroid dysfunction in DUB. J Adv Res Bio Sci. 2013;5(1):78-839.

Ajmani NS, Sarbhai V, Yadav N, Paul M, Ahmad A, Ajmani AK. Role of thyroid dysfunction in patients with menstrual disorders in tertiary care center of walled city of Delhi. J Obstet Gynecol India. 2016;66(2):115-9.

Singh P, Dubey P, Yadav S, Yadav SS. Thyroid abnormality in abnormal uterine bleeding: an observational study from Medical College in Western UP, India. Int J Reprod Contracept Obstet Gynecol. 2018;7:308-11.






Original Research Articles