Comparative study of labetalol and nifedipine in management of hypertensive disorders in pregnancy


  • U. S. Hangarga Department of Obstetrics and Gynaecology, Navodaya Medical College, Raichur, Karnataka, India
  • Rita D. Department of Obstetrics and Gynaecology, SDM Medical College, Dharwad, Karnataka, India
  • K. Harshitha



Nifedipine, Labetalol, Hypertension mean arterial pressure, PIH, Pre-eclampsia


Background: Hypertensive disorders complicate 5 to 10 percent of all pregnancies, and together they are one member of the deadly triad, of haemorrhage and infection.

Methods: The Present study was conducted at Navodaya Medical College, Hospital and Research Centre, Raichur from January 2014 to December 2015. The efficacy of labetalol verses nifedipine in management of hypertensive disorders of pregnancy was studied. The study consisted of 100 antenatal patients irrespective of parity and gestational age from 20-40weeks patients, with severe PIH with imminent eclampsia. Heart diseases, Hematological disorders, Liver diseases renal diseases and Bronchial asthma were excluded from the study.

Results: In the study, fall in mean arterial pressure of >20mm Hg was noted 6hrs after initiation of treatment in nifedipine group which is statistically significant; no statistical significance was observed in both groups at 12hrs. A fall of mean arterial pressure to normal was noted at 48hrs and 72 hrs in labetalol, which is statistically highly significant.

Conclusions: The present study indicates labetalol to be a better anti-hypertensive in terms of control of hypertension, mode of vaginal delivery and fetal outcome.

Author Biography

K. Harshitha

Department of Obstetrics and Gynaecology, Navodaya Medical College, Raichur, Karnataka, India


Sibai BM, Grossman HG. Effects of diuretics on plasma volume in pregnancies with long term hypertension. Am J Obstetr Gynecol. 1984;150: 831-5.

Sibai MB. A comparison of no medication versus methyldopa or labetalol in chronic hypertension during pregnancy. Am J Obstet Gynecol. 1990;162:960-7.

Pickles CJ, Broughton Pipkin F, Symonds EM.A randomized placebo controlled trial of labetalol in the treatment of milk to moderate pregnancy induced hypertension. Br J Obstet Gynecol. 1992;99:964-8.

McDonald AJ, Yealy DM, Jacobson S.Oral labetalol verusus oral nifedipine in hypertensive urgencies in the ED. Am J Emerg Med. 1993;11:460-3.

Lindheimer MD. Hypertension in pregnancy. Hypertension. 1993;22:127-37.






Original Research Articles