Published: 2019-07-26

Ovarian teratomas: clinicopathological study at tertiary care center

Sunil Vitthalrao Jagtap, Nitin S. Kshirsagar, Shubham S. Jagtap, Saswati Boral, Nitesh Nasre


Background: Teratomas are belonging to a group of germ cell tumors. It is also referred to as dermoid cyst. Teratomas are most common germ cell tumor of the ovary. Teratomas are composed of various histological types. In this article we are presenting various morphological patterns, its clinical manifestation and its clinical significance.

Methods: This is prospective study for a period of 3 years from March 2016 to February 2019 at tertiary care hospital. It consists of total evaluation of 82 cases of ovarian lesions which were surgically excised for clinically or radiologically suspected of ovarian neoplasm.

Results: A total of 82 cases of ovarian specimen were included out of which 18 cases were of ovarian teratoma. In these 17 cases were benign teratomas, 1 case of immature teratoma. All the cases of mature teratoma were predominantly of cystic type with focal solid areas. Right sided ovary was involved in44.5% cases while left sided in 55.5% cases. The tumor size ranges from 2.5 cm to 20.8 cms. The age range in this study was from 20 to 60 year. The common age observed for ovarian teratoma was in group of 31-40 years, having 6 cases. The clinically most of cases were asymptomatic or presented with unexplained abdominal pain or palpable mass. USG finding in most of cases were diffuse or partial echogenic mass lesion with cystic nature and echogenic bands.

Conclusions: In our study showed mature cystic teratoma is the most common type of ovarian teratomas. The immature and monodermal types are rare. The histopathological examination plays important role in final diagnosis   and patient management.


Gonad, Ovarian neoplasm, Ovarian cyst, Teratoma

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Wesselschmidt RL. The teratoma assay: an in vivo assessment of pluripotency. Methods Mol Biol. 2011;767:231-41.

Linder D, McCaw BK, Hecht F. Parthenogenic origin of benign ovarian teratomas. N Engl J Med. 1975;292:63-6.

Caruso PA, Marsh MR, Minkowitz S, Karten G. An intense clinicopathologic study of 305 teratomas of the ovary. Cancer. 1971;27:343-8.

Comerci JT, Licciadi F, Bergh PA. Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of literature. Obstet Gynecol. 1994;84:22-8.

Thurlbeck WM, Scully RE. Solid teratoma of the ovary. A clinicopathologic analysis of 9 cases. Cancer. 1960;13:804-11.

Ulbright TM. Gonadal teratoma review and speculation. Adv Anat Pathol. 2004;11:10-23.

Kumar V, Abbas AK, Fausto N. The female genital tract: Pthologic Basis of diseases, 8th Ed. Sanuders; 2010: 1047-1048.

Chiang AJ. Squamous cell carcinoma arising from mature cystic teratoma of the ovary. Int J Gynecol Cancer. 2011;21:466-74.

Schneider DT, Terenziani M, Cecchetto G, Olson TA. Gonadal and extragonadal germ cell tumors, sex cord stromal and rare gonadal tumors. In: Schneider D, Brecht I, Olson T, Ferrari A, editors. Rare tumors in children and adolescents. Pediatric Oncol Berlin Springer; 2011: 327-402.

Kim MJ, Kim NY. Clinical characteristics of ovarian teratoma: age focused retrospective analysis of 580 cases. Am J Obstet Gynecol. 2011;205:e1-e32.

Al-Fozan H, Glassman J, Caspi B, Appelman Z, Tulandi T. Lateral distribution of ovarian dermoid cyst. J Am Assoc Gynecol Laparosc. 2003;10:489-90.

Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic teratomas of the ovary: diagnostic value of sonography. AJR Am J Roentgenol. 1998;171:1061-5.

Guerriero S, Mallarini G, Ajossa S. Transvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal women. Ultrasound Obstetr Gynecol. 1997;9:339-43.

Quirk JT, Natarajan N. Ovarian cancer incidence in the United States, 1992-1999. Gynecol Oncol. 2005;97:519-23.

Nogales F, Talerman A, Kubik-Huch RA, Tavassoli FA, Devouassoux-Shisheboran M. In: World Health Organisation. Classification of Tumours. Pathology and Genetics Tumours of the Breast and Female Genital Organs. Tavassoli FA, Devilee P, eds. Lyon: IARC Press; Germ Cell Tumours; 2003:163-175.

Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, et al. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol. 1998;22:1115-24.

Young RH. New and unusual aspects of ovarian germ cell tumors. Am J Surg Pathol. 1993;17:1210-24.

Jagtap SV, Dhawan SD, Jagtap SS, Kshirsagar NS. Mucinous cystadenocarcinoma ovary presented as giant pelvic-abdominal mass. Int J Med Sci Pub Health. 2016;3:10:1305-8.

Park SB, Kim JK, Kim K, Cho KS. Imaging findings of complications and unusual manifestations of ovarian teratomas. Radiographics. 2008;28(4):969