Maternal and fetal outcome of heart disease in pregnancy: an audit in a tertiary hospital in India
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20193507Keywords:
Fetal outcome, Heart disease, High-risk pregnancy, Manifestations of heart disease, Maternal outcome, PregnancyAbstract
Background: There has been a rising incidence of pregnancy complicated by heart disease in India. The importance of heart disease in pregnancy lies in its high morbidity and mortality in both maternal and fetal outcomes combined with lack of enough established guidelines in its management.
Methods: A study was done in department of obstetrics and gynaecology, KEM hospital, Mumbai from January 2016 to April 2017 retro prospectively studying the different manifestations of heart disease in pregnancy and the maternal and fetal outcomes.
Results: During the study period, there were 6500 deliveries in the study center and of them 135 presented with heart disease. Of the 135 cases observed, 100 cases came under the inclusion criteria and were included in the study. The incidence of heart disease in pregnancy in the current institute is 2%. In the 100 cases, 55% were seen to have Rheumatic heart disease, 32% with cyanotic and acyanotic congenital heart disease and 13% with other conditions such as peripartum cardiomyopathy and mitral valve prolapse. Maternal outcome shows 44 patients delivered vaginally, 21 by assisted vaginal delivery and 35 required caesarean section. Maternal adverse cardiac events comprised of heart failure seen in 11 cases, ICU admissions required in 14 patients and maternal mortality in one case. Neonatal outcome comprised of 31 preterm births, still births 2, low birth weight seen in 41 and 16 needing NICU admissions.
Conclusions: Early diagnosis and prompt management with a multidisciplinary approach is fundamental in managing a case of heart disease in pregnancy.
References
Nanna M, Stergiopoulos K. Pregnancy complicated by valvular heart disease: J Am Heart Assoc. 2014;3(3):e000712.
Khairy P, Ionescu-Ittu R, Mackie AS, Abrahamowicz M, Pilote L, Marelli AJ. Chan- ging mortality in congenital heart disease. J Am Coll Cardiol. 2010;56(14):1149-57.
Konar H, Chaudhuri S. Pregnancy complicated by maternal heart disease: a review of 281 women. J Obstet Gynaecol India. 2012;62(3):301-6.
Pearson GD, Veille JC, Rahimtoola S, Hsia J, Oakley CM, Hosenpud JD, et al. Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) workshop recommendations and review. JAMA. 2000;283(9):1183-8.
Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001;104(5):515-21.
Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, et al. Outcome of pregnancy in women with congenital heart disease: a literature review. J Am Coll Cardiol 2007;49(24):2303-11.
Weiss BM, von Segesser LK, Alon E. Outcome of cardiovascular surgery and pregnancy: a systematic review of the period 1984-1996. Am J Obstet Gynecol. 1998;179(6):1643-53.
Avila WS, Rossi EG, Ramires JA, Grinberg M, Bortolotto MR, Zugaib M. Pregnancy in patients with heart disease: Experience with 1,000 cases. Clin Cardiol. 2003;26(3):135-42.
Salam S, Mushtaq S, Mohi-ud-din K, Gul I, Ali A. Maternal and fetal outcome in pregnancy with heart disease in tertiary care hospital in India. Int J Reprod Contracept Obstet Gynecol. 2017;6(9):3947-51.
Siu SC, Sermer M, Colman JM. Prospective multicenter study of pregnancy outcome in women with heart disease. Circulation. 2001;104(5):515-21.
Weiss BM, von Segesser LK, Alon E, Seifert B, Turina MI. Outcome of cardiovas- cular surgery and pregnancy: a systematic review of the period 1984 - 1996. Am J Obstet Gynecol. 1998;179(6):1643-53.
Chambers CE, Clark SL. Cardiac surgery during pregnancy. Clin Obstet Gynecol. 1994;37(2):316-23.
Becker RM. Intracardiac surgery in pregnant women. Ann Thorac Surg. 1983;36:453-8.
Puri S, Bharti A, Puri S, Mohan B, Bindal V, Verma S. Maternal heart disease and pregnancy outcomes. JK Sci. 2013;15(1):7-10.
Bonanno C, Gaddipati S. Mechanisms of hemostasis at cesarean delivery. Clin Perinatol. 2008;35(3):531-47.
Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, et al. Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J. 2007;28(2):230-68.
Abildgaard U, Sandset PM, Hammerstrom J, Gjestvang FT, Tveit A. Management of pregnant women with mechanical heart valve prosthesis: thromboprophylaxis with low molecular weight heparin. Thromb Res. 2009;124(3):262-7.
Devabhaktuni P, Devinenik K, Vemuri U. Pregnancy outcome in chronic rheumatic heart disease. J Obstet Gynaecol India. 2009;59(1):41-6.
Centers for Disease Control and Prevention (CDC). U S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep. 2010;59(RR-4):1-86.