Perivellosa disease massive fibrin deposition, association with Down syndrome: case report and literature review

Authors

  • Cristobal Barragan Ochoa Department of Medicine, Naval Postgraduate School Health, Coyoacan, Mexico
  • Raul D. Lara Sanchez Department of Medicine, Naval Postgraduate School Health, Coyoacan, Mexico
  • Junior J. Araiza Navarro Department of Medicine, Naval Postgraduate School Health, Coyoacan, Mexico
  • María I. Tolentino Sosa Gynecologist-Obstetrician, Gynecology-Obstetrics Service of the Hospital General of High Naval Specialty (HOSGENAES), Coyoacán Delegation, Mexico
  • Tania P. Alvarez Dominguez Pathologist-Oncologist, Pathology Service, General Hospital of the High Naval (HOSGENAES), Mexico
  • Roberto Rivera Villanueva Radiologist, Specialist in Ultrasound, Radiology and Imaging General Hospital High Specialty Hospital, Mexico

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20164501

Keywords:

Fetal growth restriction, Fibrin deposition, Globular placenta, Maternal floor infarction, Therapy

Abstract

The disease perivellosa massive fibrin deposition (MPFD), is a condition characterized by uncontrolled mainly fibrin deposition intervillous space. The incidence worldwide is 0.028% per 1000 live births, there is only one case report where this condition is associated with trisomy 21, in our country there are no reports of this disease. The MPFD has high morbidity, obstetric mortality, recurrence, as well as neurodevelopmental significance of newborns. The etiology until the moment is unknown, difficult diagnosis and management for the obstetrician. The aim is to report MPFD association with trisomy 21 (T21) and a review of the medical literature regarding this condition.

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References

Bane A, Gillan J. Massive perivillous fibrinoid causing recurrent placental failure. An Int J Obstet Gynaecol. 2003;110:292-5.

Redline R. Classification of placental lesions. Am J Obstet Gynecol. 2015;213(4):S21-8.

Romero R, Whitten A, Korzeniewski S, Than N, Chaemsaithong P, Miranda J. Maternal floor infarction/Massive perivillosu fibrin deposition: A manifestation of maternal antifetal rejection. Am J Reprod Immunol. 2014;70(4):285-98.

Faye P, Ernst L. Maternal Floor Infarction and Massive Perivillous Fibrin Deposition. Surg Pathol Clin. 2013;6(1):101-14.

Gogia N, Machin G. Maternal Thrombophilias Are Associated with Specific Placental Lesions. Pediatr Dev Pathol. 2008;11:424-9.

Uxa R, Baczyk D, Kingdom JCP, Viero S, Casper R, Keating S. Genetic Polymorphisms in the Fibrinolytic System of Placentas with Massive Perivillous Fibrin Deposition. Placenta. 2010;31(6):499-505.

Katzman P, Genest D. Maternal Floor Infarction and Massive Perivillous Fibrin Deposition: Histological Definitions, Association with Intrauterine Fetal Growth Restriction , and Risk of Recurrence. Pediatr Dev Pathol. 2002;5:159-64.

Pinar H, Goldenberg R, Koch M. Placental findings in singleton stillbirths. Obstet Gynecol. 2014;123(2 Pt 1):325-36.

Günyeli I, Erdemoğlu E, Ceylaner S, Zergeroğlu S, Mungan T. Histopathological analysis of the placental lesions in pregnancies complicated with IUGR and stillbirths in comparison with noncomplicated pregnancies. J Turkish Ger Gynecol Assoc. 2011;12(2):75-9.

Andres R, Kuyper W, Resnik R, Piacquadio K, Benirschke K. The association of maternal floor infarction of the placenta with adverse perinatal outcome. Am J Obstet Gynecol. 1990;163(3):935-8.

Jindal P, Regan L, Fourkala EO, et al. Placental pathology of recurrent spontaneous abortion: The role of histopathological examination of products of conception in routine clinical practice: A mini review. Hum Reprod. 2007;22(2):313-6.

Linn R, Kiley J, Minturn L, Fritsch M, Dejulio T, Rostlund R. Recurrent Massive Perivillous Fibrin Deposition in the Placenta Associated with Fetal Renal Tubular Dysgenesis : Case Report and Literature Review. Pediatr Dev Pathol. 2013;16:378-86.

Yu W, Tellier R. Coxsackie Virus A16 Infection of Placenta with Massive Perivillous Fibrin Deposition Leading to Intrauterine Fetal Demise at 36 Weeks Gestation. Pediatr Dev Pathol. 2015;18(4):331-4.

Weber M, Nikkels P, Hamoen K, Duvekot J, de Krijger R. Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol. 2006;9(3):234-8.

Al-adnani M, Kiho L, Scheimberg I. Recurrent Placental Massive Perivillous Fibrin Deposition Associated with Polymyositis : A Case Report and Review of the Literature. Pediatr Dev Pathol. 2008;11:226-9.

Al-Sahan N, Grynspan D, Von Dadelszen P, Gruslin A. Maternal floor infarction: Management of an underrecognized pathology. J Obstet Gynaecol Res. 2014;40(1):293-6.

haiworapongsa T, Romero R, Korzeniewski S. Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD). J Matern neonatal Med. 2015;0:1-8.

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Published

2016-12-20

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Section

Case Reports