Evaluation of Podocalyxin level in pre-eclampsia with severe features' patients: a cross-sectional study

Ahmed F. Amin; Hisham Abou-Taleb; Mustafa Gamal; Marwa M. Thabet; Nashwa Azoz; Ahmed M. Abbas

doi:10.18203/2320-1770.ijrcog20193545

Authors

Ahmed F. Amin Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Hisham Abou-Taleb Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt
Mustafa Gamal Department of Obstetrics and Gynecology, Luxor International Hospital, Luxor, Egypt
Marwa M. Thabet Department of Clinical Pathology, Assiut University, Assiut, Egypt
Nashwa Azoz Department of Internal Medicine Faculty of Medicine, Assiut University, Assiut, Egypt
Ahmed M. Abbas Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20193545

Keywords:

High risk pregnancy, Hypertension with pregnancy, Podocalyxin, Preeclampsia, Renal function tests, Renal injury

Abstract

Background: This study aims to evaluate the level of podocalyxin (PCX) in preeclampsia with severe features patients and correlate it with the results of laboratory tests.

Methods: The current study was a cross-sectional study conducted in Assiut Women Health Hospital between April and October 2018. The study included 60 patients divided into two groups; Group (A): 30 patients diagnosed to have preeclampsia with severe features and Group (B): 30 patients as normal control group. Complete laboratory investigations with measurements of the PCX level was performed for all study participants.

Results: No statistically significant difference between the study group and control group according to blood urea (p= 0.339) and serum creatinine (p= 0.801).There was statistically significant difference between the study group and control group according to PCX level (p= 0.001); the mean PCX was 3340.0 ± 2394.6 in the study group versus 1083.5±1400.2 in the control group. Univariate analysis revealed podocalyxin was not correlated with clinical data or laboratory investigations.

Conclusions: Podocalyxin levels were significantly elevated in preeclampsia.

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