DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20193545

Evaluation of Podocalyxin level in pre-eclampsia with severe features' patients: a cross-sectional study

Ahmed F. Amin, Hisham Abou-Taleb, Mustafa Gamal, Marwa M. Thabet, Nashwa Azoz, Ahmed M. Abbas

Abstract


Background: This study aims to evaluate the level of podocalyxin (PCX) in preeclampsia with severe features patients and correlate it with the results of laboratory tests.

Methods: The current study was a cross-sectional study conducted in Assiut Women Health Hospital between April and October 2018.  The study included 60 patients divided into two groups; Group (A): 30 patients diagnosed to have preeclampsia with severe features and Group (B): 30 patients as normal control group. Complete laboratory investigations with measurements of the PCX level was performed for all study participants.

Results: No statistically significant difference between the study group and control group according to blood urea (p= 0.339) and serum creatinine (p= 0.801).There was statistically significant difference between the study group and control group according to PCX level (p= 0.001); the mean PCX was 3340.0 ± 2394.6 in the study group versus 1083.5±1400.2 in the control group. Univariate analysis revealed podocalyxin was not correlated with clinical data or laboratory investigations.

Conclusions: Podocalyxin levels were significantly elevated in preeclampsia.


Keywords


High risk pregnancy, Hypertension with pregnancy, Podocalyxin, Preeclampsia, Renal function tests, Renal injury

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