The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia

Isha Sunil; Mitali Sharma

doi:10.18203/2320-1770.ijrcog20193802

Authors

Isha Sunil Department of Obstetrics and Gynecology, Acharya Shri Chander College of Medical Sciences, Jammu, J&k, India
Mitali Sharma Department of Obstetrics and Gynecology, Acharya Shri Chander College of Medical Sciences, Jammu, J&k, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20193802

Keywords:

Preeclampsia, Predictive marker, sFlt-1/PIGF ratio

Abstract

Background: Hypertensive disorders of pregnancy constitute a major cause of maternal morbidity and mortality. Pre-eclampsia/eclampsia ranks second only to haemorrhage as a specific, direct cause of maternal mortality. A number of markers have been under study for the early detection of this disease. The study aims to evaluate the predictive value of sFlt-1/PlGF ratio for preeclampsia.

Methods: This study was conducted in the Department of Gynaecology and Obstetrics of ASCOMS hospital, Jammu for a period of 6 months from Jan 2019 to June 2019. 50 antenatal patients attending the outpatient department with risk factors for developing preeclampsia were enrolled in the study. Their sFlT-1/PIGF ratio was determined at gestational age of 20 weeks to 37 weeks and its predictive value was evaluated.

Results: In the present study, 8 patients developed preeclampsia subsequently. The mean sFlt-1/PIGF ratio values were significantly higher in the patients who developed preeclampsia (73.5) than who did not develop the disease (26.07). The positive predictive value at 1 week was 41.66% and negative predictive value was 100%. At 4 weeks, positive predictive value was 66.66% and negative predictive value was 100%.

Conclusions: The present study suggests sFlt-1/PIGF ratio values are useful marker was a predictor of preeclampsia and values >38 were associated with preeclampsia. It is more useful in ruling out preeclampsia than ruling in the disease.

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