Management of pseudohypoparathyroidism in pregnancy: a rare entity

Mrinalini Sinha, Anjum Ara, Indu C. Chug, Saunri Hansadah, Avani Goyal


Pseudohypoparathyroidism is a very rare genetic disorder and during pregnancy poses multiple challenges related to its monitoring and management. Authors present the case of a  30year old primigravida who was a diagnosed case of pseudohypoparathyroidism since 22 yrs of age, presented to our obs/gynae OPD at 5+5 wks of POG. She was managed by serial monitoring of serum calcium, phosphate and vitamin D throughout  pregnancy with careful dose modification of calcium from 1gm to 3.5gm daily and vitamin D from  0.5mcg  to 1.5mcg daily. During her course of pregnancy, she developed gestational hypothyroidism, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and gestational hypertension which were controlled and managed successfully. She had an elective caesarean section at 37+6 wks POG for transverse lie. Both maternal and perinatal outcome were good. Patient was discharged with advice to continue with her monitoring of serum calcium, phosphate, vitamin D along with supplementation of calcium and vitamin D life long.


Pseudohypoparathyroidism, Serum calcium, Vitamin D

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Mantovani G. Pseudohypoparathyroidism diagnosis and treatment. J Clin Endocrinol Metabol. 2011;96(10):3020-30.

Ramallo PG. Management of pseudohypoparathyroidism in pregnancy: case report. J Obstet Gynaecol. 2016;37(4):519-20.

Singh A, Agarwal N. Management of pseudohypoparathyroidism type 1a during pregnancy and labor: case report. Hindawi Pub Corp Case Repo Obstet Gynecol. 2012;Article ID 629583:2.

Gershberg H, Weseley AC. Pseudohypoparathyroidism and pregnancy. The J Paediatr. 1960;56(3):383-6.

Ochiai D. Pseudohypoparathyroidism type 1a in pregnancy. J Obstet Gynaecol. 2013;33(8):900.

O’Donnell D, Costa J, Meyers AM. Management of pseudohypoparathyroidism in pregnancy: Case report. Br J Obstet Gynaecol. 1985;92(6):639-41.