DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20200334

Thyroid disorders in pregnancy: prevalence and its fetomaternal outcome in a tertiary hospital of Delhi, India

Neha Bansal, Divya .

Abstract


Background: This study was conducted to determine the feto maternal outcome in pregnant women with thyroid disorders. The prevalence of thyroid disorders in present study was 15.75%.

Methods: This was a prospective observational study carried out in all pregnant women irrespective of their parity, who attended ANC clinic in department of obstetrics and gynaecology in a tertiary care hospital over a period of 2 years. After registering, the patients were followed up with routine antenatal visits up to delivery and records were reviewed for development of abortion, PIH, preterm delivery, GDM, anemia, placental abruption, still birth, anomalies, fetal distress, meconium stained liquor, low birth weight and neonatal outcome by neonate Apgar score and TSH value.

Results: Mean age group in our study was 27.61±3.14. Family history was present in 8% of study group versus 0% in control group which was statistically significant (p=0.028). Eighteen percent of preeclampsia was diagnosed in study group as compared to 4% in control group which was statistically significant (p-value= 0.005). Fourteen percent patients had preterm labour in study group as compared to 6.7% in control group which was statistically significant (p value= 0.047). Increased neonatal TSH was found in study group (61.3%) as compared to control group (32%), this difference was statistically significant (p-value <0.001). There was increased importance of measuring TSH in first trimester as it was statistically significant in study group (p-value <0.001).

Conclusions: All pregnant women should be screened for hypothyroidism as early as possible or before conception to prevent any fetomaternal complications.


Keywords


Delivery, Fetomaternal outcome, Hypothyroidism, Pregnancy, Prevalence, Thyroid stimulating hormone

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References


Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081-125.

Vanita RS, Anahita CR. Thyroid disorders in pregnancy. Fogsi Focus: Thyroid womb to brain M. Caetomb. 2006:32-6.

Misra R. Other medical disorders. In: Ian Donald’s Practical Obstetrical Problems. 7th ed. New Delhi: BI publications; 2014:242.

Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L, et al. The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy. Eur J Endocrinol. 2011:164(2):263-8.

Taghavi M, Saghafi N, Shirin S. Outcome of thyroid dysfunction in pregnancy in Mashhad, Iran. Int J Endocrinol Metab. 2009;2:82-5.

Ajmani SN, Aggarwal D, Bhatia P, Sharma M, Sarabhai V, Paul M. Prevalence of overt and subclinical thyroid dysfunction among pregnant women and its effect on maternal and fetal outcome. J Obstet Gynecol India. 2014;64(2):105-10.

Nambiar V, Jagtap VS, Sarathi V, Lila AR, Kamalanathan S, Bandgar TR, et al. Prevalence and impact of thyroid disorders on maternal outcome in Asian-Indian pregnant women. J Thyroid Res. 2011;2:4290-7.

Dhanwal DK, Bajaj S, Rajput R, Subramaniam K, Chowdhury S, Bhandari R, et al. Prevalence of hypothyroidism in pregnancy: an epidemiological study from 11 cities in 9 states of India. Indian J Endocr Metab. 2016;20(3):87-90.

Saeed AK, Yassin K, Elmahdi EMA, Maralyn D, Ali AA. The prevalence of thyroid dysfunction among sudanese pregnant women. SOJ Gynecol Obstet Womens Health. 2015;1(1):5.

Saraladevi R, Kumari T, Shreen B, Rani V. Prevalence of thyroid disorder in pregnancy and pregnancy outcome. Inter Arch Integ Med. 2016;3(3):1-11.

Singh A, Reddy MJ. Prevalence of thyroid dysfunction in pregnancy and its implications. Int J Med Sci Public Health. 2015;4:1247-50.

Sahu MT, Das V, Mittal S, Agarwal A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstetr. 2010;281(2):215.

Thanuja PM, Rajgopal K, Sadiqunnisa. Thyroid dysfunction in pregnancy and its maternal outcome. J Dent Med Sci. 2014;13(1):11-5.

Idris I, Srinivasan R, Simm A, Page RC. Maternal hypothyroidism in early and late gestation; effects on neonatal and Obstetric outcome. Clin Endocrinol. 2015;63:560-5.