Published: 2019-09-26

Scenario of molar pregnancy in a tertiary care centre in Delhi, India

Seema Pundir, Vinita Gupta, Sonal Prasad


Background: Molar pregnancies represent a significant burden of disease on the spectrum of gestational trophoblastic diseases with incidence varying with geographic region. Aim was to review all molar pregnancies admitted at our institution and to study the incidence, clinical presentation, management, complications and outcome of molar pregnancies.

Methods: An observational study was done in department of obstetrics and gynaecology at Dr. BSA Medical College and Hospital among women with molar pregnancy over two years.

Results: The incidence of molar pregnancy of the institute was 1.05/1000 deliveries. 21- 25 years age group and nulliparous women constituted 28.1% of patients. Amenorrhea (100.0%) was the commonest presenting complaints followed by abnormal vaginal bleeding (90.62%). Anemia (37%) was the commonest complication followed by acute hemorrhage (31%) and hyperthyroidism (18%). Suction evacuation was done in 96.8% of patients and 87.5% required blood transfusion. Only 6.2% (2/32) of patients had post evacuation chemotherapy. None of the cases developed choriocarcinoma. Limitation of the study was that the incidence of subsequent pregnancies after complete treatment of molar pregnancies was not studied.

Conclusions: Early diagnosis of complete molar pregnancy can change the clinical presentation, diagnosis, and treatment of molar pregnancy. There is need for early recognition, timely referral, prompt and proper treatment of this condition. Adequate follow-up of the patients and need for contraception should be reinforced.


Gestational trophoblastic diseases, H mole, India, Molar pregnancy, Suction evacuation, Vaginal bleeding

Full Text:



Lurain I, John R. Gestational trophoblastic disease: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531-9.

Newlands ES, Paradinas FJ, Fisher RA. Recent advances in gestational trophoblastic disease. Hematol Oncol Clin North Am. 1999;13:225.

Bracken MB, Brinton LA, Hayashi K. Epidemiology of hydatidiform mole and choriocarcinoma. Epidemiol Rev. 1984;6:52-75.

Kaye DK. Gestational trophoblastic disease following complete hydatidiform mole in mulago hospital, Kampala, Uganda. Afr Health Sci. 2002;2:47-51.

Agboola A. Trophoblastic tumours. Textbook of Obstetrics and Gynaecology for Medical Students. 2nd ed. Ibadan: Heinemann Educational Books (Nigerian) Plc. 2006:218-224.

Eniola OA, Mabayoje P, Ogunniyi SO. Hydatidiform mole in Ile-Ife, Nigeria: A 10 year review. J Obstet Gynaecol. 2001;21:405-7.

Aghajanian P. Gestational trophoblastic disease. In: Decherney AH, Nathan L, Goodwin TM, Laufer N, editors. Current Diagnosis Treatment in Obstetrics and Gynaecology 10th ed. New York: Mc Craw Hill Medical Publishing Division. 2007:885-895.

Srangsriwong S. Molar pregnancy in sappasithiprasong hospital. Med J Ubon Hosp. 1995;16:187-94.

Savage P, Seckl M. Trophoblastic Disease. In: Edmond KD, editor. Dewhurst’s Textbook of Obstetrics and Gynaecology. 7th ed. UK: Black Well Publishing, Inc. 2007:117-124.

Obiechina NJ, Udigwe GO, Obi RA. Molar pregnancy: A ten year review at onitsha, Nigeria. J Med Invest Pract. 2001;3:26-31.

Fernando RJ, Williams AA, Adams EJ. Royal College of Obstetricians and Gynaecologists. The management of third and fourth degree perineal tears. RCOG Green top Guidelines No 29. 2007.

Dutta DC. Haemorrhage in early pregnancy. In: Konar H, editor. DC Dutta’s Textbook of Obstetrics and Gynaecology. 7th ed. London: New Central Book Agency P Ltd. 2011:158-199.