DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20160565

AmnioQuick® Duo+ for diagnosis of premature fetal membranes rupture

M. Lutfi AbuFaza, Ibrahim A. Abdelazim, Mohammed M. Al-Sherbeeny, Mohamed E. M. Ibrahim, Noha H. Rabei, Sreelatha R. Nair

Abstract


Background: Failure to identify women with premature fetal membranes rupture associated with infectious morbidities. Evaluation of the accuracy of AmnioQuick® Duo+ in diagnosing premature fetal membranes rupture compared to conventional diagnostic tests was the aim of this study.

Methods: 220 pregnant women ≥37 and <39 weeks` gestation studied and classified into two groups; study group (premature fetal membranes rupture) and control group (no premature fetal membranes rupture). Participants examined by trans-abdominal ultrasound (TAS) and vaginal speculum to visualize amnion leaking and for collection of samples for fern, nitrazine and AmnioQuick® Duo+ tests on admission. A final diagnosis whether the studied women had PROM or not at the initial presentation made after delivery.

Results: Sensitivity and specificity of the AmnioQuick® Duo+ to diagnose PROM was 93.6% and 86.4%; respectively compared with 72.7% and 80.9%; respectively for fern test and 76.4% and 83.6%; respectively for nitrazine test. Positive predictive value, negative predictive value and accuracy of AmnioQuick® Duo+ to detect PROM were 87.3%, 93.1% and 90%; respectively compared with 79.2%, 74.8% and 76.8%; respectively for fern test and 82.4%, 77.97% and 80%; respectively for nitrazine test. AmnioQuick® Duo+ test had higher accuracy to detect premature fetal membranes rupture compared to conventional diagnostic tests.

Conclusions: AmnioQuick® Duo+ is accurate bedside immunoassay test, better than the individual conventional diagnostic tests and can used as complementary test to improve the management of women with women premature fetal membranes rupture.

Keywords


AmnioQuick® Duo+, Premature fetal membranes rupture

Full Text:

PDF

References


ACOG Committee on Practice Bulletins-Obstetrics. Clinical management guidelines for obstetrician-gynecologists. (ACOG Practice Bulletin No. 80: premature rupture of membranes). Obstet Gynecol. 2007;109:1007-19.

Medina TM, Hill DA. The Florida Hospital Family Practice Residency Program, Orlando that begins: (Preterm premature rupture of membranes). Am Fam Phys. 2006;73:659-664.

Abdelazim IA, Abdelrazak KM, Al-Kadi M, Yehia AH, Abdulkareem AF. Fetal fibronectin (Quick Check fFN test) versus placental alpha microglobulin-1 (AmniSure test) for detection of premature rupture of fetal membranes. Arch Gynecol Obstet. 2014;290(3):457-64.

Ruanphoo P, Phupong V. Evaluation of the performance of the insulin-like growth factor-binding protein-1/alpha-fetoprotein test in diagnosing ruptured fetal membranes in pregnant women. J Perinatol. 2015;35(8):558-60.

Wang T, Zhou R, Xiong W, Wang Y, Zhu C, Song C. Clinical evaluation of soluble intercellular adhesion molecule-1 and insulin like growth factor-binding protein-1-based rapid immunoassays for the diagnosis of prelabor rupture of membranes. J Perinat Med. 2013;41:181-5.

Caughey AB, Robinson JN, Norwitz ER. Contemporary Diagnosis and Management of Preterm Premature Rupture of Membranes. Rev Obstet Gynecol. 2008;1(1):11-22.

Abdelazim IA, Makhlouf HH. Placental alpha microglobulin-1 (AmniSure® test) for detection of premature rupture of fetal membranes. Arch Gynecol Obstet. 2012;285(4):985-9.

Kim YH, Park YW, Kwon HS, Kwon JY, Kim BJ. Vaginal fluid beta human chorionic gonadotropin in level in the diagnosis of premature rupture of membranes. Acta Obstet Gynecol Scand. 2005;84:802-5.

Cooper AL, Vermillion ST, Soper DE. Qualitative human chorionic gonadotropin testing of cervicovaginal washings for the detection of preterm premature rupture of membranes. Am J of Obstet & Gynecol. 2004;191(2):593-7.

Esim E, Turan C, Uanl O, Dansuk R, Cengizglu B. Diagnosis of premature rupture of membranes by identification of beta-HCG in vaginal washing fluid. Eur J Obstet Gynecol Rprod Boil. 2003;107(1):37-40.

Abdelazim IA. Fetal fibronectin (Quick Check fFN test®) for detection of premature rupture of fetal membranes. Arch Gynecol Obstet. 2013;287(2):205-10.

Abdelazim IA, Makhlouf HH. Placental alpha microglobulin‐1 (AmniSure test) versus insulin‐like growth factor binding protein‐1 (Actim PROM test) for detection of premature rupture of fetal membranes. J Obstet Gynaecol Res Research. 2013;9(6):1129-36.

Abdelazim IA. Insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes. J Obstet Gynaecol Res. 2014;40(4):961-7.

Tagore S, Kwek K. Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy. J Perinat Med. 2010;38:609-12.

Chen FC, Dudenhausen JW. Comparison of two rapid strip tests based on IGFBP-1 and PAMG-1 for the detection of amniotic fluid. Am J Perinatol. 2008;25:243-6.

Aboulenien W, Azzam A, Saleh F, Abollo M, Soliman A. Insulin-like growth factor binding protein-1 in cervico-vaginal secretions as an indicator of premature rupture of membranes: comparison with nitrazine test and amniotic fluid index. Int J of Gynecol & Obstet. 2009;107S2:S413-S729.

Marcellin L, Anselem O, Guibourdenche J, De la Calle A, Deput-Rampon C, Cabrol D. Comparison of two bedside tests performed on cervicovaginal fluid to diagnose premature rupture of membranes. J Gynecol Obstet Biol Reprod. 2011;40(7):651-6.

Albayrak M, Ozdemir I, Koc O, Ankarali H, Ozen O. Comparison of the diagnostic efficacy of the two rapid bedside immunoassays and combined clinical conventional diagnosis in prelabour rupture of membranes. Eur J Obstet Gynecol Reprod Biol. 2011;158(2):179-82.

Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes and preventive tools for preterm birth. J Matern Fetal Neonatal Med. 2011;24(5):659-67.

El-Messidi A, Cameron A. Diagnosis of Premature Rupture of Membranes: Inspiration from the Past and Insights for the Future. Journal of Obstetrics & Gynaecology Canada. 2010;32(6):561-9.

Gallot D, Guibourdenche J, Sapin V, Goffinet F, Doret M, Langer B. Which biological test to confirm rupture of membranes? J Gynecol Obstet Biol Reprod. 2012;41(2):115-21.

Thomasino T, Levi C, Draper M, Neubert AG. Diagnosing rupture of membranes using combination monoclonal/polyclonal immunologic protein detection. J Reprod Med. 2013;58:187-94.