DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20194898

Atypical proliferative Brenner tumour of the ovary with liver metastases: a case report

Saaliha Vali, Mohamed Oumar, Shefali Chavhan, Olga Wise, Ahmed Sayasneh

Abstract


Brenners tumours constitute up to 2% of ovarian neoplasms. Most are benign with a gross fibroma like appearance. Here we present the case of a 45 year old woman who underwent a full staging laparotomy for a suspicious left ovarian mass. A 30 cm left ovarian cyst was found with no enlarged lymph nodes. Histologically this was a proliferative Brenner tumour. Postoperatively, a mild increase in the Ca125 prompted an MRI scan which revealed a 3 cm liver cyst. This was resected and histologically found to be a transitional cell carcinoma. Successful treatment with secondary excision and adjuvant chemotherapy has ensured disease free remission to date.


Keywords


Brenners, Ca125, Liver, Neoplasm, Ovarian, Tumour

Full Text:

PDF

References


Brenner F. Ds oophoroma folliculare. Frankf Z Pathol. 1907;1:150-71.

Hemalatha AL, Konanahalli P. Bilateral malignant Brenner tumor of ovary. J Obstet Gynecol India. 2005;55:81-2.

Kuhn E, Ayhan A, Shih IeM, Seidman JD, Kurman RJ. Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. Eur J Cancer. 2013;49:3839-49.

Roma AA, Masand RP. Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study. Hum Pathol. 2014;45:2417-22.

Riedel I, Czernobilsky B, Lifschitz-Mercer B, Roth LM, Wu XR, Sun TT, et al. Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. Virchows Arch. 2001;438:181-91.

Hallgrìmsson J, Scully RE. Borderline and malignant Brenner tumours of the ovary. A report of 15 cases. Acta Pathol Microbiol Scand Suppl. 1972;233:56-66.

Roth LM, Sternberg WH. Proliferating Brenner tumors. Cancer. 1971;27:687-93.

Shaco-Levy R, Benharroch D. Vaginal Brenner tumor. Int J Gynecol Pathol. 2013;32:238-41.

Robinson TG. Extraovarian Brenner tumor. J Obstet Gynaecol Br Emp. 1950;57:890-1.

Quan J, Jin L, Hu J, He T, Pan X, Ding Y, et al. Brenner tumor of the testis: a case report and review of the literature. Mol Clin Oncol. 2017;6:119-21.

Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: review and case report. Gynecol Oncol Rep. 2017;22:26-31.

Yue Z, Si T, Pan Z, Cao W, Yan Z, Jiang Z et al. Malignant Brenner tumor of the ovary: clinical, pathological and demographic analyses of 10 cases. Int J Clin Exp Pathol. 2016;9:5642-6.

Yamamoto R, Fujita M, Kuwabara M, Sogame M, Ebina Y, Sakuragi N, et al. Malignant Brenner tumors of the ovary and tumor markers: case reports. Jpn J Clin Oncol. 1999;29:308-13.

Ben Aissia N, Sadfi A, Youssef A, El Ayeb A, Chadli A, Mzabi R, et al. Malign Brenner’s tumor particularities and coverage. Tunis Med. 2004;82:701-7.

Nasioudis D, Sisti G, Holcomb K, Kanninen T, Witkin SS. Malignant Brenner tumors of the ovary; a population-based analysis. Gynecol Oncol. 2016;142:44-9.

Riedel I, Czernobilsky B, Lifschitz-Mercer B, Roth LM, Wu XR, Sun TT, et al. Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. Virchows Arch. 2001;438(2):181-91.

Han JH, Kim DY, Lee SW, Park JY, Kim JH, Kim YM, et al. Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: an analysis of 10 cases within a single center. Taiwan J Obstet Gynecol. 2015;54:178-82.

Dierickx I, Valentin L, Van Holsbeke C, Jacomen G, Lissoni AA, Licameli A, et al. Imaging in gynecological disease: clinical and ultrasound features of Brenner tumors of the ovary. Ultrasound Obstet Gynecol. 2012;40:706-13.

Takahama J, Ascher SM, Hirohashi S, Takewa M, Ito T, Iwasaki S, et al. Borderline Brenner tumor of the ovary: MRI findings. Abdom Imaging. 2004;29:528-30.

Heintz AP, Odicino F, Maisonneuve P, Quinn M.A, Benedet JL, Creasman WT, et al. Carcinoma of the ovary. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95:161-92.

Austin RM, Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J Gynecol Pathol. 1987;6:29-39.

Cuatrecasas M, Catasus L, Palacios J, Prat J. Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. Am J Surg Pathol. 2009;33:556-67.