Assessment of maternal serum β hCG level in pregnancy induced hypertension and normotensive patients and to correlate between the level of β hCG with the severity of pre-eclampsia and eclampsia

Kapil Dev, Anoop Sharma, Rajeev Sood


Background: Hypertensive disorders during pregnancy are one of the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Spectrum of this disease ranges from mildly elevated blood pressure with minimal clinical significance to severe hypertension with multi organ dysfunction. Pre-eclampsia complicates about 2-8% of all pregnancies. Pre-eclampsia incidence in India is about 8-10%. Various studies have depicted that, there is a strict relationship between PIH and elevated serum β-hCG level.

Methods: This one-year prospective case control study toteled 200 pregnant women attending antenatal care and admitted in eclampsia ward fulfiling the inclusion criteria were studied. Serum βhCG levels were estimated by chemiluminescent microparticle immunoassay. Statistical analysis of data was done by student’s t-test and p-value.

Results: The mean β hCG level in PIH patients was found to 36851.59 mIU/ml with standard deviation of 22916.58 while the mean β hCG in normotensive patient was 15433.26 mIU/ml with standard deviation of 6861.56. (p <0.001). The mean β hCG level in gestational hypertensive patients was 25206.19 mIU/ml with a standard deviation of 8696.9. The mean β hCG level in pre-eclamptic patients was 61697.67 mIU/ml with standard deviation of 18498.57. The mean β hCG level were 84106.38 mIU/ml with standard deviation of 11295.05 in the eclamptic patient. The above values were statistically significant (p <0.001).

Conclusions: We concluded that there was a striking relation between the PIH including pre-eclampsia and eclampsia with the elevated serum βhCG level. Concluding that early detection of altered serum βhCG shell aid in better management of pre-eclampsia and eclampsia cases which would play a pivotal role in improving the maternal and fetal outcome.


βhCG, Pregnancy induced hypertension, Pre-eclampsia and eclampsia

Full Text:



Mallick MP, Ray S, Medhi R, Bisai S. Eleveted serum beta hCG and dyslipidimia in second trimester as predictor of subsequent pregnancy induced hypertension. Bangladesh Med Res Counc Bull. 2014;40:97-101.

Dubey P, Pandey K, Agarwal S, Jain S, Singh N, Gupta S. Effect of Raised midtrimester serum hCG and alfa fetoprotein on pregnancy outcome. Indian J Clin Pract. 2013;23(10):645-7.

Sharma V, Sharma P, Firdous N. Beta hCG in mid trimester as a predictor of pregnancy induced hypertension. Int J Sci Res. 2016;5(9):303-5.

Modi DA, Rami BD, Wander GK. Role of serum βhcg and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. Int J Res Med. 2015;4(4):34-7.

Yadav S, Shrivastav N, Paneri S, Pawar P. The study of beta hCG level along with general biochemical profile in pre-eclampsia. IOSR J Dent Med Sci. 2014;13(7):28-1.

Singh A, Khambra P, Rani KU, Mandal AK. Assessment of serum βhCG, lipid profile and uric acid levels in early second trimester as predictors of pregnancy induced hypertension. Ann Pathol Lab Med. 2016;3(3):157-61.

Yadav V, Rathore K, Kaushik GG. A study of beta human chorionic gonadotrophin level in Pre-eclampsia and normotensive pregnant women. Int J Sci Res. 2015;4(3):1832-3.

Chowdhary H, Kurshid R, Praveen S. Utility of second trimester beta hCG levels in prediction of gestational hypertension: a prospective cohart study. Int J Reprod Contracept Obstet Gynaecol. 2017;6(3):1040-4.

Dzudor B, Seini MM, Annan BDRT, Srofenyoh E, Kudzi W. The significance of serum level of magnesium and human chorionic gonadotrophin in singleton pregnant women diagnosed with pre-eclempsia. Int J Adv Res.2014;2(12):569-80.

Remzi G, Erdal A, Nursel B, Ozcan B. Elevated serumβ hCG level in sever pre-eclempsia. Turk J Med Sci. 2000;(30):43-5.

Khatun J, Amir S. In the pre-eclampsia and normotensive patient- lipid profile study. Med Today. 2017;29(2):1-3.

Begum Z, Ara I, Tanira S, Keya KA. The association between serumβ hCG and pre-eclempsia. J Dhaka Med Coll. 2014;23(1)89-93.

Chaudhary KM, Das M, Gosh S, Bhattacharya D, Gosh TK. Value of serum beta hCG in pathogenesis of Pre-eclempsia. J Clin Gynaecol Obstet. 2012;1(4-5):71-5.

Dyal M, Gupta P, varma M. Role of second trimester maternal serum marker as predictor of pre-eclampsia. J Obstet Gynaecol India. 2011;61(1):38-41.

Sindhu PC. Role of second trimester maternal serum marker as predictor of pre-eclampsia. Int J Med Applied Sci. 2013;2(4):238-43.