DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20195343

Ormeloxifene versus combined oral contraceptive pills to control blood loss in cases of dysfunctional uterine bleeding

Ankita Gupta, Rishika Raj

Abstract


Background: Dysfunctional uterine bleeding is one of the most often encountered gynecologic problems causing anemia, reduced quality of life and unnecessary hysterectomies. A prospective study was conducted on women with DUB to study the effect of ormeloxifene versus combined oral contraceptive pills in controlling blood loss in them.

Methods: 100 Women with DUB were enrolled randomly in three groups. After baseline assessment each patient in group A was treated with iron tablets, containing 100 mg elemental iron and folic acid 1.5 mg, for three months and were termed as control group. Group B patients were treated with ormeloxifene in dose of 60 mg twice a week for twelve weeks. Group C patients were treated with combined oral contraceptive pills for twenty- one days starting from third day of their LMP. The treatment was continued for three consecutive cycles. The efficacy of the studied drugs was analyzed by comparing the baseline and post treatment PBAC score, haemoglobin level and endometrial thickness, using appropriate statistical tests.

Results: Ormeloxifene was more effective than only iron or combined oral contraceptive therapy in controlling menstrual blood loss (79.11% versus 58.57%). There was a reduction in endometrial thickness in group receiving ormeloxifene as well as in the group receiving combined oral contraceptive pills (p=0.486), however this was statistically not significant.

Conclusions: Ormeloxifene was significantly better than combined OCP in reduction of menstrual blood flow in cases of DUB. It has better compliance and marked improvement in subjective symptoms as compared to OCP.


Keywords


Centchroman, Combined oral contraceptive pills, Dysfunctional uterine bleeding, Ormeloxifene, Pictorial Blood loss assessment chart, Selective estrogen receptor modulators

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References


Crosignani PG, Rubin B. Dysfunctional uterine bleeding. Human Reprod. 1990;5:637-8.

Fraser IS. The dysfunctional uterus - dysmenorrhoea and dysfunctional uterine bleeding. In: Shearman RP, editor. Textbook of clinical reproductive endocrinology. Edinburgh: Churchill Livingstone; 1985:578-598.

Fraser IS, Hickey M, Song JY. A comparison of mechanisms underlying disturbances of bleeding caused by spontaneous dysfunctional uterine bleeding or hormonal contraception. Hum. Reprod. 1996;11(Suppl 2):165-78.

Fraser IS, Sungurtekin U. Defining menstrual disturbances. In: Maclean A, O’Brien PMS, editors. Study Group on Menstrual Disorders. Royal College of Obstetricians and Gynaecologists. 2000;141-152.

Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Hum Reprod Update. 2002;8:60-7.

Patel SR, Sheth MS, Rawal MY. Dysfunctional uterine bleeding place for hysterectomy in its management. J Postgrad Med. 1986;32:150-3.

Sonoda, Barakat R, Richard. Screening and the prevention of gynecologic cancer: Endometrial cancer. Best practice and research. Clin Obstet Gynaecol. 2006;20:363-77.

Higham JM, O’ Brien PMS, Shaw RW. Assessment of menstrual blood loss using a pictorial chart. Br J Obstet Gynaecol. 1990;97:734-9.

Milsom I. The levonorgestrel releasing intra uterine system as an alternative to hysterectomy in perimenopausal women. Contra. 2007;75:S152-S154.

Kriplani A, Singh BM, Lal S, Agarwal N. Efficacy, acceptability and side effects of the levonorgestrel intra uterine system for menorrhagia. Int J Gynaecol Obstet. 2007;97:190-4.