Effects of clomiphene citrate on seminal parameters in idiopathic oligospermia: a single blinded prospective randomized controlled trial


  • Apurba Mandal Department of Obstetrics and Gynecology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
  • Shibram Chattopadhyay Department of Obstetrics and Gynecology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
  • Chandan Sasmal Department of Obstetrics and Gynecology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
  • Tapan Kumar Maiti Department of Obstetrics and Gynecology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
  • Shritanu Bhattacharyya Department of Obstetrics and Gynecology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India




Clomiphene citrate, Idiopathic oligospermia, Male factor infertility, Pregnancy rate, Semen analysis, Sperm count


Background: About 15% married couples face problem of infertility of which male factor is implicated in 20% of them. In about 30% infertile men no causative factor is found and the condition is termed “Idiopathic”. They are often treated by empirical medications or Assisted Reproductive Technologies (ART) although success in few; our present study is carried on effects of clomephene citrate on seminal parameters in idiopathic oligospermia.

Methods: This single blinded prospective randomized controlled trial was conducted at the infertility clinic with 200 idiopathic oligospermic men (sperm count <15 millions/ ml of ejaculate) after fulfilling inclusion and exclusion criteria and were alternately allocated into two equal groups - “Group C” receiving clomephene citrate tablets and “ Group P” receiving placebo after concealment. Semen analysis data were collected at baseline and every month and three months of completion of treatment and were summarized by routine descriptive statistical analysis.

Results: The demographic characteristics like mean age is comparative in both groups but duration of infertility of >2 years is more in group C than group p (4.3±3.06 versus 4.1±2.57). The semen volume, spermatozoa count, sperm motility and not normal form are all increased after three months of treatment in group C as are biochemical parameters like total testosterone and serum FSH, LH and as also pregnancy rate (22% versus 4%).

Conclusions: This study showed clomiphene citrate treatment protocol is inexpensive, relatively safe and easy to administer and improves semen volume, sperm count and sperm motility but not sperm morphology by increasing serum testosterone, FSH and LH in male and resulting in improved pregnancy rate in female partners.


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