Comparison of intravenous iron sucrose with oral iron in pregnant women with iron deficiency anaemia

Samar Rudra; Archana Chandna; Jayati Nath

doi:10.18203/2320-1770.ijrcog20160577

Authors

Samar Rudra Department of Obstetrics and Gynaecology, MMIMSR, Mullana, Ambala, India
Archana Chandna Department of Obstetrics and Gynaecology, MMIMSR, Mullana, Ambala, India
Jayati Nath Department of Obstetrics and Gynaecology, MMIMSR, Mullana, Ambala, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20160577

Keywords:

Iron sucrose, Haemoglobin, Anaemia

Abstract

Background: The aim of this study was to compare the efficacy and safety of intravenous iron sucrose with oral iron in the treatment of iron deficiency anaemia in pregnancy.

Methods: 200 pregnant women with gestational age between 24 to 34 weeks with Hb 7.0-9.0 g/dL and peripheral smear features suggestive of iron deficiency anaemia were included in the study and they were randomized in two groups of 100 each. Group A: IV iron group was given 200 mg of Iron sucrose complex in 200 ml of normal saline IV drip, 3 days a week till her calculated required dose has been infused. Group B: oral iron group received ferrous ascorbate oral tablets equivalent to 100 mg elemental iron twice a day during her pregnancy. Various laboratory parameters like hemoglobin, reticulocyte count, PCV, MCV, MCH, MCHC as well as serum ferritin were measured at recruitment and at 1week, 2 weeks, 4 weeks of starting treatment, at delivery and at 3 months postpartum. Haemoglobin and ferritin level of cord blood was also measured. Any adverse effects of drug were noted in both the groups. All the relevant data were tabulated and statistical analysis was done.

Results: The change in all the assessed parameters including haemoglobin and ferritin levels from baseline was significantly higher in the intravenous group than the oral group at each point of measurement. IV iron group did not have any serious adverse drug reactions and oral group experienced adverse effects mainly gastrointestinal symptoms.

Conclusions: Intravenous iron sucrose treated iron deficiency anaemia of pregnancy faster, and more effectively than oral iron therapy, with no serious adverse drug reactions.

Metrics

Metrics Loading ...

References

WHO global database on child growth and malnutrition, Geneva: WHO programme on nutrition. 1997.

Bhatt RV. Maternal mortality in India, FOGSI- WHO study. J Obstet Gynecol India. 1997;47:207-14.

Viteri FE. The consequences of iron deficiency and anaemia in pregnancy. Adv Exp Med Biol. 1994;352:127-39.

National Family Health Survey (NFHS-3), Ministry of health and family welfare (Government of India). 2005-2006.

Agarwal KN, Agarwal DK, Sharma A, Sharma K, Prasad K, Kalitaetal MC. Prevalence of anaemia in pregnant & lactating women in India.Indian J Med Res. 2006;124:173-84.

American College of Obstetricians and Gynecologists: Nutrition during pregnancy, Washington. ACOG. 1993:1-7.

NKF-K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease: Update 2000. Am J Kidney Dis. 2001;37:S182-S238.

Govan AD, Scott JM. Intravenous iron in the treatment of anemia of pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005;123(2):S33-S35.

Dalal M, Ranjan R, Seth S. Comparison of Oral and Intravenous Iron for Treatment of Iron Deficiency Anaemia in Pregnancy. Indian Medical Gazette. 2002:372-5.

Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 Years experience with iron-sucrose complex. Br J Nutrition. 2002;88:3-10.

Yee J, Besarab A. Iron sucrose: The oldest iron therapy becomes new. Am J Kid Dis. 2002;40:1111-21.

Unlubilgin E, Kandemir O, Yalvac S. Intravenous versus oral iron for treatment of anaemia in pregnancy: a randomized trial. Obstet Gynaecol. 2005;106:1335-40.

Momen AK, Meshari A, Nuaim L. Intravenous iron sucrose complex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 1996;69:121-4.

Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anemia in pregnancy: Intravenous route Versus oral route. Am J Obstet Gynecol. 2002;186:518-22.

Abhilasini GD, Sangili H, Rani R. Intravenous iron sucrose and oral iron for the treatment of iron deficiency anaemia in pregnancy: Journal of Clinical and Diagnostic Research. 2014;8(5):4-7.

DeebaShafi, Purandare SV, Sathe AV. Iron deficiency anaemia in pregnancy: Intavenous vs. oral route. J of Obstet Gynaecol India. 2012;62(3):317- 21.

Ragip A, Unlubilgin E, Kandemir O, Yalvac S, Cakir L, Haberal A. Intravenous versus Oral iron treatment of anaemia in pregnancy: a randomized trial. Obstet Gynaecol. 2005;106:1335-40.

Khalafallah A, Dennis A, Bates J. A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy. Journal of Internal Medicine. 2010;268(3):286-95.