DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20194861

A prospective study of thyroid dysfunction in dysfunctional uterine bleeding

Chaithra M., Anitha G. S., Savitha C.

Abstract


Background: Dysfunctional uterine bleeding is abnormal uterine bleeding in the absence of any palpable pelvic pathology and demonstrable extra genital causes. Thyroid dysfunction is the systemic disease most often associated with abnormal uterine bleeding. Aim was to evaluate thyroid function test in women with DUB; to assess bleeding pattern in thyroid dysfunction.

Methods: Prospective observational study was done in the department of obstetrics and gynaecology, Vanivilas hospital, Bangalore from august 2018 to July 2019. Pre structured and predesigned proforma filled. All routine blood investigations including serum T3, T4, TSH, USG were advised. These patients were categorized as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid based on thyroid profile.

Results: 0.5% belonged to the age group of 31-40 years, prevalence of subclinical hypothyroidism is 11%, there were 5.5% of cases of hypothyroidism and 1.5% case of hyperthyroidism.

Conclusions: Thyroid screening must be done mandatory for all the cases of DUB and prompt response to treatment with thyroxine would avoid unnecessary surgeries, hormonal treatment, and associated comorbities.


Keywords


Anaemia, Dysfunctional uterine bleeding, Thyroid

Full Text:

PDF

References


Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health-related quality of life, work impairment, and health-care costs and utilization in abnormal uterine bleeding. Value Health. 2007;10:183-94.

Bhavani N, Sathineedi A, Chippa S, Reddy VSP. A study of correction between abnormal uterine bleeding and thyroid dysfunction. Int J Recent Trends Sci Tech. 2015;14(1):131-5.

Davey DA. Text book of obstetrics and gynaecology for post graduates. DUB, 5th edition. 1990:590-600.

Cowan BD, Morrison JC. Management of abnormal genital bleeding in girls and women. N Engl J Med. 1991;324:1710-5.

Berek JS, Adarshi EY, Hillard PA. In endocrine disorders. Novaks Gynaecology. 12th edn. Williums &Wilkins. 2001:864.

Krassas GE. Thyroid disease and female reproduction. Fertil Steril. 2000;74:1063-70.

Ross GT, Scholz DA, Lambert EH. Severe uterine bleeding and degenerative skeletal muscle changes in unrecognized myxoedema. J Clin Endocrinol. 1958;18:492-500.

Joshi JV, Bhandarkar SD, Chandha M. Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre. J Postgraduate Med. 1993;39(3):137-41.

Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health related quality of life, work impairment and health care costs and its utilization in abnormal uterine bleeding. Value Health. 2007;10:183-94.

Thomas R, Reid RL. Thyroid disease and reproductive dysfunctions. Obstet Gynaecol. 1987;70:789-98.

Fraser IS, Langham S, Hoschgraebes K. Health related quality of life and economic burden of abnormal uterine bleeding, Expert Review Obstet Gynaecol. 2009;4(2):179-89.

Sruthi T, Shivanna SB, Gopal N. Prevalence of hypothyroidism in patients with provisional diagnosis of DUB. J Evolution Med Dental Sci. 2014;3(11):2967-72.

Bhardwaj M, Bhargava S. Study of thyroid function in dysfunctional uterine bleeding. National J Med Dental Res. 2015;4(1):6-10.

Verma SK, Pal A, Jaswal S. A study of thyroid dysfunction in dysfunctional uterine bleeding. Int J Reprod Contracep Obst Gynaecol. 2017;6(5):2035-9.

Deshmukh PY, Borichia BG, Pandey A. The association of thyroid disorders with abnormal uterine bleeding. Int J Reprod Contracep Obstet Gynaecol. 2015;4(3):701-8.