DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20195348

Estimation and comparison of serum lipid profile of women with pregnancy induced hypertension and normal pregnancy

Kapil Dev, Rajeev Sood, Aanya Sharma

Abstract


Background: Hypertensive disorders during pregnancy are the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Raised blood pressure in pregnancy is the major cause of fetomaternal morbidity and mortality. The most important feature in preeclampsia is hypertension which is supposed to be due to vasospastic phenomenon in kidney, uterus, placenta and brain. Altered lipid synthesis leading to decrease in PGI2:TXA2 ratio is also supposed to be an important way of pathogenesis in pregnancy induced hypertension.

Methods: This one-year prospective case control study total 200 pregnant women attending antenatal care and admitted in eclampsia ward fulfiling the inclusion criteria were studied. Serum lipid profile was estimated by semiautomatic analyzers. Statistical analysis of data was done by student’s t-test and p-value.

Results: Mean total cholesterol in pregnancy induced hypertension was 278.5±52.52 mg/dl and normal pregnancy was 245.47±20.075 mg/dl. Mean triglycerides in pregnancy induced hypertension was 249.88±92.575 mg/dl and normal pregnancy was 206.89±46.345 mg/dl. Mean HDL in pregnancy induced hypertension was 43.69±4.135 mg/dl and normal pregnancy was 49.9±6.501 mg/dl. Mean LDL in pregnancy induced hypertension was 174.43±39.083 mg/ dl and normal pregnancy was 151.22±19.92 mg/dl. Mean VLDL in pregnancy induced hypertension was 46.885±15.143 mg/dl and in normal pregnancy was 40.964±9.061 mg/dl, total cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides were increased in pregnancy induced hypertension when compared to normal pregnancy, which is statistically significant.

Conclusions: We concluded that the Patient who developed pre-eclampsia have abnormal lipid profile. This abnormal lipid profile is responsible for endothelial dysfunction. This endothelial dysfunction may play a key role the pathophysiology of pre-eclampsia. Early detection of these parameters may help patient by preventing complications and is going to aid in better management of pre-eclampsia.


Keywords


Pregnancy induced hypertension, Pre-eclampsia and eclampsia, Serum lipid profile

Full Text:

PDF

References


Mallick MP, Ray S, Medhi R, Bisai S. Eleveted serum beta hCG and dyslipidimia in second trimester as predictor of subsequent pregnancy induced hypertension. Bangladesh Med Res Counc Bull. 2014;40:97-101.

Modi DA, Rami BD, Wander GK. Role of serum βhcg and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. Int J Res Med. 2015;4(4):34-7.

Phalak P, Tilak M. Study of lipid profile in Pre-eclampsia. Indian J Bas Appl Med Res. 2012;5(2):405-9.

Saha D, Roy P, Pal R. Serum lipid profile- how it alter in normotensive and hypertensive pregnant women. J Evolut Med Dent Sci. 2013;2(31):5895-902.

Kiran Y, Shalini A, Kamlesh V. Serum bhCG and lipid profile in early second trimester as predictors of pregnancy-induced hypertension. The J Obstet Gynecol India. 2014;64(3):169-74.

Nayan S, Meena ML, Hooja N, Fatima A, Singh N, Aseri S. A study of comparison of serum lipid profile of women with pregnancy induced hypertension and normal pregnancy. Sch Acad J Biosci. 2014;2(11):834-6.

Singh A, Khambra P, Rani KU, Mandal AK. Assessment of serum βhCG, lipid profile and uric acid levels in early second trimester as predictors of pregnancy induced hypertension. Ann Pathol Laborat Med. 2016;3(3):157-61.

Kalar MU, Kalar N, Mansoor F, Malik AR, Lessley T, Kreimer S, et al. Preeclampsia and lipid levels - a case control study. Int J Collaborat Res Inter Med Pub Health. 2012;4(10):1738-45.

Anuradha R, Durga T. Estimation of lipid profile among preeclampsia woman by comparing with normal pregnancy. Int J Contemp Med Res. 2016;3(7):1958-61.

De J, Mukhopadhyay AK, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Boichem. 2006;21(2):722-7.

Shivanagappa M, Singh S, Sujatha MS, Mahadevaih M. Comparative study of lipid profile in normotensive and hypertensive pregnant women. Inte J Sci Stu. 2015;3(7):222-5.

Khatun J, Amir S. In the pre-eclampsia and normotensive patient- lipid profile study. Med Today. 2017;29(2):1-3.

Yadav S, Shrivastav N, Paneri S, Pawar P. The study of beta hCG level along with general biochemical profile in pre-eclampsia. IOSR J Dent Med Sci. 2014;13(7):28-1.

Sahu S, Abraham R, Vedavalli R, Daniel M. Study of lipid profile, lipid peroxidation and vitamin e in pregnancy induced hypertension. Indian J Physiol Pharmacol. 2009;53(4):365-9.

Gawande MS, Joshi SA. Lipid profile in patients of pre-eclampsia: a comparative study. Panacara J Med Sci. 2016;6(3):155-8.