Effects of estrogens and progestagens on the primary variables of haemostasis

Eliana Ibrahimi, Mynyr Koni


Background: The present study aims at determining the effect of two combined oral contraceptives on the primary variables of haemostasis in a group of healthy Albanian women.

Methods: In this study were included, 49 women between the ages of 24 and 51 years, twenty nine of them taking ethinylestradiol 30 μg and gestodene 75 μg and twenty of them taking ethinylestradiol 30 μg and levonorgestrel 75 μg for 1-2 months. The subjects had no history of thromboembolic disease. Plasma was used for measuring levels of PT, fibrinogen, factors V and VIII, before and after pill use. Collected data were analyzed using SPSS 20 software.

Results: Comparison of values of the parameters before and after treatment showed that concentrations of fibrinogen and factor VIII were significantly increased following treatment (p<0.05), while we noted no significant changes in the level of factor V. Prothrombin time and activated thromboplastin time were reduced during treatment (p>0.05).

Conclusions: The results show that changes in the haemostatic primary variables after combined oral contraceptive administration are significant which might increase the risk for thrombotic situations.


Estrogens, Progestagens, Blood coagulation, Factor VIII, Factor V

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