DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20196025

Study of sociodemographic profile, maternal, fetal outcome in preeclamptic and eclamptic women: a prospective study

Vedavathi ., Rajeev Sood

Abstract


Background: Preeclampsia is pregnancy specific disease, lead to maternal, perinatal morbidity and mortality. This study is conducted to identify the socio demographic profile of subjects suffering from preeclampsia and its effect on maternal and fetal health.

Methods: This prospective study was conducted at department of obstetrics and gynecology, Kamla Nehru State Hospital, Shimla, in this, 100 preeclamptic women were included. Preeclampsia was diagnosed with blood pressure of ≥140/90 mmHg noted for the first-time during pregnancy, after 20 wks of gestation and proteinuria. Demographic details were collected. Investigations i.e. hemogram, liver and renal function tests, coagulation profile and fundoscopy were done. Maternal and perinatal outcomes were recorded.

Results: In this study, majority of the subjects were primigravida 65. In this, 11 subjects had systolic blood pressure of 140-159 mmHg and 89 subjects had systolic blood pressure of > 160 mmHg. 25 subjects had diastolic blood pressure of 90-109 mmHg and 75 subjects had diastolic blood pressure of > 110 mmHg. In this, 82 subjects had warning symptoms, mainly headache 49. 14 subjects showed hypertensive changes in fundus. Unfavorable Bishop Score, observed in 86 subjects and 78 subjects were induced after controlling blood pressure. Majority of subjects had vaginal delivery 73. Majority of the subjects had deranged liver function 61. Maternal morbidity was reported in 54 subjects. Intrauterine death reported in 14 subjects. Birth weight was < 2.5 kg was observed in 70 babies. Out of 74 live births, 53 neonates required admission in NICU and 16 neonates died in NICU.

Conclusions: It may be concluded that, maternal and neonatal morbidity and mortality can be reduced by early identification of risk factors and timely intervention is the hall mark in preventing the maternal and perinatal morbidity and mortality.


Keywords


Fetal complications, Intrauterine death, Maternal complications, Severe preeclampsia, Unfavorable bishop score

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References


Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi J. Preeeclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467-74.

Duley L. The global impact of preeclampsia and eclampsia. Semin Perinatal. 2009;33:130-7.

Arora R, Ganguli RP, Swain S, Oumachigui A, Rajaram P. Determinants of maternal mortality in eclampsia in India. Aust NZJ Obstet Gynaecol. 1994;34:537-9.

Registrar General, India centre for global health research, University of toranto, Canada Maternal mortality in India1997-2003 trends causes and risk factors (internet) New Delhi Registrar General India, 2006. Available at: http://www.health.mpgov.in/ maternal mortality in India 1997-2003.

Peres GM, Mariana M, Cairrão E. Pre-Eclampsia and eclampsia: an update on the pharmacological treatment applied in Portugal. J Cardiovasc Dev Dis. 2018;5(3):1-13.

Dhananjaya BS, Venkatesh G, Sendil Kumadan D. Study of correlation between oxidative stress parameters and severity of preeclampsia. Int J Biol Med Res. 2012;3(1):1260-2.

Rukmini MS, Kowsalya R, Pai B, Das P, Perriera J, Nandini M, et al. Plasma adenosine deaminase activity and antioxidant status in preeclampsia comapred to healthy pregnant and nonpregnant women. Biomed Res. 2009;20(1):15-20.

Oztas E, Ozler S, Tokmak A, Erel O, Ergin M, Uygur D, et al. Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity-preliminary report. Ginekologia Polska. 2016;87(6):436-41.

Sanchez-Aranguren LC, Prada CE, Riano-Medina CE, Lopez M. Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 2014;5:1-11.

Dekker G, Sukcharoen N. Etiology of preeclampsia: An update. J Med Assoc Thai. 2004;87(3):S96-S103.

The Federation of Obstetric and Gynecological Societies of India (FOGSI) FOCUS. Pregnancy induced Hypertension 2007;1-44. Available at: https://www.fogsi.org/fogsi-focus-pregnancy-indu ced-hypertension/.

Buchbinder A, Sibai BM, Caritis S, MacPherson C, Hauth J, Lindheimer MD, et al. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol 2002; 8186:66-71.

Ramesh K, Gandhi S, Rao V. Socio-demographic and other risk factors of pre-eclampsia at a tertiary care hospital, Karnataka: case control study. Journal of clinical and diagnostic research. JCDR. 2014;8(9):JC01-4.

Singhal SR, Deepika, Anshu, Nanda S. Maternal and perinatal in severe preeclampsia and eclampsia. South Asian Federation Obstet Gynaecol. 2009;1(3):25-8.

Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of preeclampsia /eclampsia and its adverse outcomes in Low and Middle-income countries: A WHO Secondary analysis. PLoS ONE. 2014;9(3):e91198.

Ganesh KS, Unnikrishan B, Nagaraj K, Jayaram S. Determinants of preeclampsia: a case - control study in District Hospital in South India. Indian J Comm Med. 2010;25(4):502-5.

Reddy PVS, Chippa S, Bhavani N, Mukhopadhyay B. Epidemiological study of pregnancy induced hypertension. Int J Recent Trends Sci Technol. 2014;11(3):379-82.

Acharya S, Pal MN. Maternal and perinatal complications in pre-eclampsia. J Universal College Med Sci. 2015;3(9):21-4.

Bej P, Chhabra P, Sharma AK, Guleria K. Determination of Risk factors for preeclampsia and eclampsia in a tertiary care hospital of India. J Family Med Prim Care. 2013;2:371-5.

Trivedi K, Patel N, Rathod M. The maternal out come in antepartum eclampsia in Tertiary care hospital in India. Asia Pacific J Res. 2014;1(17):10-5.

Jadav P. Feto-maternal out come in pregnancy with eclampsia in tertiary care hospital JMSCR. 2015;3:6630-5.

Sultana, Aparna J. Risk factors for pre-eclampsia and its perinatal outcome. Ann Biol Res. 2013;4(10):1-5.

Douglas KA, Redman CW. Eclampsia in the United Kingdom. BMJ. 1994;309(6966):1395-400.

Gawde A, Bhosale UT. A study of maternal and perinatal out come in pre-eclampsia. Int J Recent Trends Sci Technol. 2014;10(2):267-70..

Ananth CV, Basso O. Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality. Epidemiol. 2010;21(1):118-23.

Abalos E, Cuesta C, Carroli G, Qureshi Z, Widmer M, Vogel JP et al. Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health. Br J Obstet Gynaecol. 2014;121:14-24.

Akhtar R, Ferdous A, Bhuiyan SN. Maternal and fetal outcome of eclamptic patients in Tertiary Hospital Bangladesh. J Obstet Gynaecol. 2011;26(2):77-80.

Dodda Mani GB, Dodda Mani GU. Perinatal out come in pre-eclampsia: a prospective study. Sch J App Med Sci. 2014;2(1):291-3.