Published: 2019-12-26

Complications and pregnancy outcome in women with preeclampsia and eclampsia

G. Thiripurasundari, D. M. Christe, S. Shobha, V. Sangeetha, Suganya Sevugaperumal


Background: One of the complications of pregnancy which till today challenges the obstetrician is preeclampsia and its severe form of eclampsia. Objective of this study was to find out the complications and outcome of pregnant women with preeclampsia and eclampsia admitted in a tertiary referral center.

Methods: Case records, in labor room, were scrutinized to find out the number and the outcome of pregnancy, in women admitted with preeclampsia or eclampsia in the year 2018.

Results: Pregnant women admitted with preeclampsia or eclampsia numbered 2511 and, 109 women developed complications. Maternal complications, were more often seen in mothers, (62.4%) of female babies. Only 37.6% of mothers of male babies developed complications. Complications seen were Renal complications in 34.8%, Hematological complications in 33%, Neurological complications in 25.6%, Pulmonary complications in 16.5%, ophthalmological complications in 11% and Sepsis in 6.4% and MODS in 10%. Of total maternal deaths, 34% was caused by complications of preeclampsia or eclampsia. Major cause of maternal death was MODS and Pulmonary complications. Nearly, 62.3% of babies born had birth weight of 1.8 kg and nearly one-third of babies (26.6%) were dead born.

Conclusions: The incidence of preeclampsia and eclampsia in our referral center for the year 2018 was 15%, and 4.3% of women developed complications, and 6% died, making preeclampsia and eclampsia the causative factor for 34% of total maternal deaths. Major maternal complications were Renal, Hematological, Neurological, Pulmonary and MODS. Complications of preeclampsia were more often present in 62.4% mothers of female babies in contrast to 37.6% of mothers of male babies. Nearly one-third of babies (26.6%) were dead born.


Complications, Eclampsia, HELPP syndrome, Preeclampsia, Renal

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Paauw ND, Lely AT. Cardiovascular sequels during and after preeclampsia. In: Kerkhof P., Miller V. (eds) sex-specific analysis of cardiovascular function. Adv Exper Med Biol Springer Cham. 2018;1065.

Lu Y, Chen R, Cai J, Huang Z, Yuan H. The management of hypertension in women planning for pregnancy. Br Med Bull. 2018;128(1):75-84.

Portelli M, Baron B. Clinical presentation of preeclampsia and the diagnostic value of proteins and their methylation products as biomarkers in pregnant women with preeclampsia and their newborns. J Preg. 2018:Article ID 2632637.

Garg RK, Kumar N, Malhotra HS. Posterior reversible encephalopathy syndrome in eclampsia. Neurol India. 2018;66(5):1316-23.

Tang P, Wang J, Song Y. Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review. BMC Preg Childbirth. 2018;18:434.

Komine-Aizawa S, Aizawa S, Hayakawa S. Periodontal diseases and adverse pregnancy outcomes. J Obstet Gynaecol Res. 2019;45(1):5-12.

Parikh P, Blauwet L. Peripartum cardiomyopathy and preeclampsia: overlapping diseases of pregnancy. Curr Hypertens Rep. 2018;20:69.

Calimag-Loyola APP, Lerma EV. Renal complications during pregnancy: In the hypertension spectrum. Dis Mon. 2019;65(2):25-44.

Konopka WD, Laskowska M, Oleszcuk J. Preeclampsia-current management and future approach. Curr Pharm Biotechnol. 2018;19(10):786-96.

Malika A, Jeeb B, Gupta SK. Preeclampsia: disease biology and burden, its management strategies with reference to India. Preg Hypertens. 2019;15:23-31.

Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467-74.

Bortolotto MR, Francisco RPV, Zugaib M. Resistant hypertension in pregnancy: how to manage? Curr Hypertens Rep. 2018;20:63.

Yan L, Jin Y, Hang H, Yan B. The association between urinary tract infection during pregnancy and preeclampsia: a meta-analysis. Med. 2018;97(36):e12192.

Khidri Ff. Various presentations of preeclampsia at tertiary care hospital of Sindh: a cross-sectional study. Current Hypertens Rev. 2019;15:1.