Correlation of lateral placental location with development of preeclampsia

Authors

  • Anjali Gupta Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India
  • Priyanka Bansal Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India
  • Jyotsna Sen Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India
  • Savita Rani Singhal Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20200867

Keywords:

Central placenta, Lateral placenta, Placenta, Preeclampsia, Ultrasonography

Abstract

Background: Preeclampsia is a complex clinical syndrome which involves multiple organ systems and remains the principle cause of maternal and perinatal morbidity and mortality. Preeclampsia is a disease of trophoblastic tissue. Placental abnormality is one of the initial events in patients who are destined to develop pregnancy induced hypertension subsequently. Objective of this study was to evaluate the association of laterally located placenta on ultrasound with development of preeclampsia.

Methods: This prospective observational study was conducted on 200 antenatal women with singleton pregnancy at 18-24 weeks of gestation who attended antenatal clinic of obstetrics and gynaecology, PGIMS Rohtak from October 2017 to October 2018. Detailed antenatal transabdominal ultrasound along with placental location was done between 18-24 weeks of gestation in women who fitted into inclusion criteria. All the antenatal women belonged to 18-24 weeks of gestation were included in the study except those women with chronic hypertension, diabetes mellitus, renal disease, severe anaemia, thyrotoxicosis, low lying placenta, previous history of preeclampsia or eclampsia.

Results: Out of 200 antenatal women, 84 had lateral placenta while 116 had central placenta. Out of these 84 women who had lateral placenta, 55 women (65.5%) developed preeclampsia and out of 116 (58%) women who had central placenta, 28 women (24.1%) developed preeclampsia.

Conclusions: From the above study, we concluded that women with laterally located placenta by ultrasound at 18-24 weeks of gestation have greater risk of developing preeclampsia.

References

Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens. 2014;4:97-104.

Studd J, Lin Tan S, Chervenak FA, editors. Current Progress in Obstetrics and Gynaecology. 4th ed. New York: Tree Life; 2017:108-154.

Cunningham FG, Veno KJ, Bloom SL. Pregnancy hypertension. In: William Obstetrics. 23rded. New York: McGraw-Hill Medical; 2010:706-756.

Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. J Am Med Assoc. 2002;287:3183-6.

Shivamurthy HM, Sharada KS, Giridhar SA, Jyotsna RH, Asaranna D. Placental laterality as a predictor of preeclampsia: an ultrasonic prospective study. J Pub Health Med Res. 2014;2:38-40.

Rivers EP. The clinical practice of emergency medicine. In: Preeclampsia, eclampsia, and other hypertensive disorders of pregnancy. 2nd edition. Lippincott Williams and Wilkins; 1996:315-321.

Kuklina EV, Ayala C, Callaghan WM. Hypertensive disorders and severe obstetric morbidity in the United States. Obstet Gynaecol. 2009;113:1299-306.

Kaku R, Shivaraju P, Vimala KR, Lingegowda K. Lateral location of placenta on ultrasound as a predictive test for pre-eclampsia. Int J Reprod Contracept Obstet Gynaecol. 2017;6:930-3.

Grill S, Rusterholz C, Zanetti- Dallenbach R, Tercanli S, Holzgreve W, Haahn S, et al. Potential markers of preeclampsia: a review. Reprod Biol Endocrinol. 2009;7:70.

Muralidhar VP, Jyothi P. Placental laterality by ultrasound: a simple yet reliable predictor test for pre-eclampsia. Indian J Obstet Gynaecol. 2005;55:431-3.

Kannamani A, Narasimhan D. A study on analysis of validity of lateral placental location in prediction of preeclampsia. J Evol Med Dent Sci. 2017;6:1401-3.

Gupta A, Kakkar M. Placental laterality as a predictor for development of preeclampsia. J Obstet Gynaecol India. 2003;63:22-5.

Gosh M, Gosh A, Sengupta P. A study to assess placental location by ultrasonography and evaluation of its relationship with development of preeclampsia and eclampsia. Int J Biomed Res. 2017;8:668-71.

Muralidhar VP, Jyothi P. Placental laterality by ultrasound: a simple yet reliable predictor test for pre-eclampsia. Indian J Obstet Gynaecol. 2005;55:431-3.

Bhalerao AV, Kulkarni S, Somalwar S. Lateral placentation by ultrasound: a simple predictor of pre-eclampsia. J South Asian Feder Obst Gynae. 2013;5:68-71.

Magann EF, Doherty DA, Turner K, Lanneau GS, Morrison JC, Newnham JP. Second trimester placental location as a predictor of an adverse pregnancy outcome. J Perinatol. 2007;27:9-14.

Kakkar T, Singh V, Ranzdan R, Sanjeev KD, Gupta A, Kakkar M. Placental laterality as a predictor for development of preeclampsia. J Obstet Gynaecol. 2012;63:22-5.

Sandhya K, Madhavi GB, Chandramathi M. Placental laterality as a predictor of pre-eclampsia. Am J Phytomed Clin Therapeut. 2015;3:231-6.

Ambastha V, Sreelatha S, Devi A, Kallesh S, Sumaiah, Kavitha LB, et al. Study of association of lateral implantation of placenta with development of preeclampsia and its outcome. The New Indian J Obstet Gynaecol. 2018;5:33-7.

Chandra K, Maheshwari S. Placental laterality: as a predictor for the development of pre-eclampsia. J Dent Med Sci. 2016;15:6-10.

Aggarwal P, Kangjam P, Terhase N. Study on relation between placental laterality in second trimester ultrasound and development of preeclampsia at term. J Evol Med Dent Sci. 2015;4:16926-8.

Bhattacharjee AK, Majumdar MK, Basumatary L. Placental laterality by ultrasound and its correlation to development of preeclampsia. Sch J App Med Sci. 2017;5:4197-200.

Salama-Bello R, Jose R, Howard S, Song J, Schenone M. Placental location and the development of hypertensive disorders of pregnancy. Am In Ultra Med. 2018;38:1-5.

Kore SJ, Khot R, Supe P, Kanavia D, Thunga C, Nandanwar Y. Prediction of pre-eclampsia: Role of placental laterality by ultrasonography. Int J Reprod Contracept Obstet Gynaecol. 2016;5:1433-7.

Seckin KD, Cakmak B, Karsali MF, Yeral MI, Gultekin B, Danisman N. Is lateral localization of placenta a risk factor for adverse perinatal outcomes. Obs Gynaecol. 2015;35:6696-8.

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Published

2020-02-27

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Original Research Articles