Published: 2019-12-26

A prospective study of maternal factors and perinatal outcome of preterm birth

Kavita Dudhrejia, Zalak V. Karena, Rahul P. Patel


Background: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality, henceforth being a major concern for the obstetricians and paediatricians as well being a major health care issue. Preventing and treating the associated risk factors could play a major role in curbing the perinatal morbidity and mortality.

Methods: A total 100 women with preterm labour or an indicated preterm termination of pregnancy were enrolled in the study. They were evaluated by history taking, clinical examination, and ultrasonography. Corticosteroids were given to all the patients. Maternal risk factors, obstetric outcome and perinatal outcome till discharge were studied.

Results: Of the 100 women studied, mean age of the cases was 27 years, 60% of the cases belonged to lower socio-economic class, 74% of the cases were under 55 kgs weight group and 77% of cases were anaemic. 34% cases were below 34 weeks of gestation, 58% were multigravida, and 2% grand multipara with 35% labour being induced labour because of presence of various risk factors such as preterm premature rupture of membranes (PPROM), pre-eclampsia, eclampsia and chorioamnionitis. 6% cases had multiple pregnancies and 8% had history of preterm delivery in previous pregnancy. Out of 107 babies, 73% neonates required neonatal intensive care unit (NICU) admission and there was 12.14% neonatal mortality rate.

Conclusions: Anaemia, malnutrition, infection, high order pregnancy are the preventable causes of preterm birth which can be prevented, screened and treated by specialised antenatal programs.


Perinatal morbidity, Perinatal mortality, Preterm birth, Preterm labour

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Pankaj D, Narendra M, Duru S. Principles and practice of obstetrics and gynaecology, 3rd ed; 2008:45-58.

Polyzos NP, Polyzos IP, Mauri D, Tzioras S, Tsappi M, Cortinovis I, et al. Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials. Am J Obstet Gynecol. 2009;200(3):225-32.

Renay W, Carine R, Ed Dorman, Hilton J, Anne M, Caroline S. Labour complications remain the most important risk factors for perinatal mortality in rural Kenya. Bull World Health Organ. 2003;81:561-6.

Shannon F, Savita C. A study of risk factors for preterm labour. Int J Repro Contracept Obstet Gynecol. 2015;4(5):1306-12.

Shlomo E, Ehud W, Zohar N, Eliezer S. Epidemiologic risk factors for preterm delivery. Isr Med Assoc J. 2002;4:1115-7.

Singh U, Singh N, Seth S. A Prospective analysis of etiology and outcome of preterm labour. The J Obstet Gynaecol India. 2007;57:48-52.

Ohmi H, Hirooka K, Mochizuki Y. Fetal growth and the timing of exposure to maternal smoking. Pediatr Int. 2002;44:55-9.

Parazzini F, Chatenoud L, Surace M, Tozzi L, Salerio B, Bettoni G, et al. Moderate alcohol drinking and risk of preterm birth. Eu J Clin Nutrit. 2003;57(10):1345.

Sebayang S, Dibley M, Kelly P, Shanka A, Anuraj H. Determinants of low birth weight, and small-for-gestational-age and preterm birth in Lombok, Indonesia: Analysis of the birth weight cohort of the SUMMIT trial. Trop Med Int Health. 2012;17(8):938-50.

Garg S, Kaur T, Saran AS, Yadav M. A study of etiology and outcome of preterm birth at a tertiary care centre. Int J Reprod Contracept Obstet Gynecol. 2017;6:4488-91.

Satija A, Satija V, Kaur J, Bains HS. Prospective analysis of preterm labour: its etiology and outcome. Int J Basic Appl Med Sci. 2014;4(2):70-7.

Sonkusare S, Rai L, Naik P. Preterm birth: mode of delivery and neonatal outcome. Med J Malaysia. 2009;64:303-6.