Sirenomelia with Potter syndrome: a case report and review of literature


  • Amrita Singh Department of Obstetrics and Gynecology, Lady Hardinge Medical College and Hospitals, New Delhi, India
  • Anupma Kumari Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India



Anhydramnios, Congenital anomaly, Limb deformity, Mermaid syndrome, Potter syndrome, Sirenomelia


Sirenomelia or mermaid syndrome is a rare congenital anomaly characterized by variable degree of fusion of lower extremities. Awareness to this rare condition is important for prenatal diagnosis and prognosticating the fetus. The exact etiopathogenesis is still an area of research. Two pathogenic hypotheses are the vascular steal hypothesis and the defective blastogenesis hypothesis with exceptions reported in literature.


Orioli IM, Amar E, Arteaga‐Vazquez J, Bakker MK, Bianca S, Botto LD, et al. Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet. 2011;157(4):358-73.

Stocker JT, Heifetz SA. Sirenomelia: a morphological study of 33 cases and review of the literature. Perspect Pediatr Pathol. 1987;10:7-50.

Kampmeier OF. On sireniform monsters, with a consideration of the causation and predominance of the male sex among them. Anat Rec. 1927;34:365.

Stevenson RE, Jones KL, Phelan MC, Jones MC, Barr M, Clericuzio C, et al. Vascular steal: the pathogenetic mechanism producing sirenomelia and associated defects of the viscera and soft tissues. Pediatr. 1986;78:451-7.

Kallen B, Winberg J. Caudal mesoderm pattern of anomalies: from renal agenesis to sirenomelia. Teratol. 1974;9:99-111.

Rodriguez JI, Palacios J, Razquin S. Sirenomelia and anencephaly. Am J Med Genet. 1991;39:25-7.

Kohler HG. An unusual case of sirenomelia. Teratol. 1972;6:295-301.

Jaiyesimi F, Gomathinayagam T, Dixit A, Amer M. Sirenomelia without vitelline arterysteal. Ann Saudi Med. 1998;18:542-4.

Thottungal AD, Charles AK, Dickinson JE, Bower C. Caudal dysgenesis and sirenomelia single centre experience suggest common pathogenic basis. Am J Med Genet. 2010;152A:2578-87.

Opitz JM, Zanni G, Reynolds JF, GilbertBarness E. Defects of blastogenesis. Am J Med Genet. 2002;115:269-86.

Duesterhoeft SM, Ernst LM, Siebert JR, Kapur RP. Five cases of caudal regression with an aberrant abdominal umbilical artery: further support for a caudal regression-sirenomelia spectrum. Am J Med Genet. 2007;143A:3175-84.

Davidson EH. Later embryogenesis: regulatory circuitry in morphogenetic fields. Development. 1993;118:665-90.

Gupta S, Araya CE. Potter syndrome. Medscape Reference, 2015. Available at: /article/983477-overview.






Case Reports