A rare case of early onset intrahepatic cholestasis of pregnancy

Authors

  • Saraswathi H. L. Department of Obstetrics and Gynecology, Chinmaya Mission Hospital, Bangalore, Karnataka, India
  • Trishula Gurunath Joshi Department of Obstetrics and Gynecology, Chinmaya Mission Hospital, Bangalore, Karnataka, India
  • Suvarna Jyothi Ganta Department of Obstetrics and Gynecology, Chinmaya Mission Hospital, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20200392

Keywords:

Intra hepatic cholestasis of pregnancy, In vitro fertilisation, Progesterone

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is an important complication of pregnancy requiring increased surveillance by the obstetricians due to its increased foetal morbidity and mortality in the form of preterm birth, foetal distress, RDS including sudden IUD and stillbirth. The incidence of ICP is increasing due to IVF and routine administration of progesterone in early pregnancy. ICP usually presents in late second and third trimester. Here authors are presenting a case of early onset ICP (14 weeks) which developed in an IVF conception.

 

References

Lammert F, Marschall H, Glantz A, Siegfried. Maternal intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management, 2000;33(6):1012-1.

Kremer AE, Martens JJ, Kulik W, Ruëff F, Kuiper EM, van Buuren HR, et al. Lysophosphatidic acid is a potential mediator of cholestaticpruritus, Gastroenterol. 2010;139(3):1008-18.

Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol. 2009;15(17):2049-66.

Glantz A, Marschall HU, Mattsson LÅ. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatol. 2004;40(2):467-74.

Müllenbach R, Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG, McCarthy MI, Williamson C. ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. J Med Genetics. 2003;40(5):e70.

Pařízek A, Dušková M, Vítek L, Šrámková M, Hill M, Adamcová K, et al. The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy. Physiol Res. 2015;64.

Maiskar V, Surve S. Early onset intrahepatic cholestasis of pregnancy: is progesterone supplementation to be blamed for?. J Obstet Gynecol India. 2019;69:192-3.

Bacq Y, Sapey T, Bréchot MC, Pierre F, Fignon A, Dubois F. Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatol. 1997;26(2):358-64.

Abu‐Hayyeh S, Papacleovoulou G, Lövgren‐Sandblom A, Tahir M, Oduwole O, Jamaludin NA, et al. Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype. Hepatol. 2013;57(2):716-26.

Bolukbas FF, Bolukbas C, Balaban HY, Aygun C, Ignak S, Ergul E, et al. Intrahepatic cholestasis of pregnancy: spontaneous vs in vitro fertilization. Euroasian J Hepato-gastroenterol. 2017;7(2):126.

Wijarnpreecha K, Thongprayoon C, Sanguankeo A, Upala S, Ungprasert P. Cheungpasitporn hepatitis C infection and intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2017;41(1):39-45.

Bull L, Vargas J. Serum bile acids in intrahepatic cholestasis of pregnancy: not just a diagnostic test. Hepatol. 2014;59(4):1220-2.

Šimják P, Pařízek A, Vítek L, Černý A, Adamcová K, Koucký M, et al. Fetal complications due to intrahepatic cholestasis of pregnancy. J Perinatal Med. 2015;43(2):133-9.

Demir BÇ, Güneş EŞ, Atalay MA. Intrahepatic cholestasis of pregnancy: relationship between bile acid levels and maternal and fetal complications. Turkish J Obstet Gynecol. 2014;11(3):148.

Puljic A, Kim E, Esakoff T, Lacoursiere D, Shaffer B, Caughey A. Maternal pregnancy complications associated with intrahepatic cholestasis of pregnancy in a population-based cohort. Am J Obstet Gynecol. 2015;212(1).

Shemer EA, Stephansson O, Thuresson M, Thorsell M, Ludvigsson JF, Marschall HU. Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: A population-based cohort study. J Hepatol. 2015;63(2):456-61.

Palmer KR, Xiaohua L, Mol BW. Management of intrahepatic cholestasis in pregnancy. The Lancet. 2019;393(10174):853-4.

Pathak B, Sheibani L, Lee RH. Cholestasis of pregnancy. Obstet Gynecol Clin North Am. 2010;37:269-82.

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Published

2020-01-28

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Case Reports