DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20200361

The tranexamic acid: as chemical tourniquet during Ward-Mayo’s operation

Sarbeswar Mandal, Sumanta Kumar Mondal, Pragati Awasthi Pathak, Kavita Agarwal

Abstract


Background: The intra-operative blood loss which required transfusion is one of the complications in Ward-Mayo’s operation. The objective of this study was to evaluate its effectiveness to minimizes hemorrhage in Ward-Mayo’s operation

Methods: It is a well-designed, Clinical, interventional, prospective, randomized control trial. In the department of obstetrics and gynecology, IPGMER-SSKM (PG) H, Kolkata, West Bengal, India. More than one-year study. After ethics approval, the total number of sixty-six cases will be selected with randomization for Ward-Mayo operation and allocated into two groups operated as - Gr-A (n = 33 cases) - by infiltrating locally tranexaminic acid, Gr-B (n = 33-controls) - application local conventional haemostatics.

Results: The outcome informs of primary and secondary assessed, analyzed, tabulated and statistically significant showed accordingly as per graph pad software. In Table 1 and 2. The results of individual group (Gr. A and Gr. B) in forms of pry and Sec. outcomes showed that there are better outcomes in all aspects with zero mortality Tranexamic group than controls.

Conclusions: This study concluded that the Tranexamic Acid can safely and effectively used by local infiltration during Ward-Mayo’ operation. Like other department, this technique can be utilized in other vaginal procedure (ex-Episiotomy).


Keywords


Better outcomes, In Ward-Mayo, Local tranexamic acid infiltration

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References


Cunningham BJ, Donnelly M, Bourke A, Murphy JE. Cardiovascular and metabolic effects of cervical Epinephrine infiltration. Obstet Gynecol. 1985;66:93.

Jullian TM, Johnson GW, Gosewehk JA, O’Connell BJ. Vasopression as chemical tourniquet during vaginal surgery. J Gynecol Surg. 1993;9:161.

Lazar MR, Kriger HA. Blood loss in vaginal surgery: a comparative study. Obstet Gynecol. 1959;13:707.

England GT, Randall HW, Graves WL. Impairment of tissues defense by vasoconstrictor in vaginal hysterectomy. Obstet Gynecol. 1983;61:271.

Evans DG, Miles AA, Niven JSF. The enhancement of bacterial infection by Adrenaline. Br J Exp Pathol. 1948;29:20.

Hamid RS, Fathi WK, Al Wattar WT. The effect of Tranexamic acid on post-surgical bleeding following removal of impacted wisdom teeth in healthy individual. Ra Fidain Dent J. 2008;8(2):225-30.

Roberts I. Tranexamic acid in trauma: how should we use it? J Thromb Haemost. 2015;13 Suppl 1:S195-9.

Eleje GV, Eke AC, Igberase GO, Igwegbe AO, Eleje LI. Cochrane Database of systemic review. 2015;5:Art:CD011000.

Chen CC, Wang CC, Wang CP, Lin TH, Lin WD, Liu SA. Prospective, randomized, controlled trial of tranexamic acid in patients who undergo head and neck procedures. Otolaryngol Head Neck Surg. 2008;138(6):762-7.

Dunn CJ, Goa KL. Tranexamic acid: a review of its use in surgery and other indications. Drugs. 1999;57(6):1005-32.