Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20200870Keywords:
Factor VIII, Recurrent pregnancy loss, ThrombophiliaAbstract
Background: Recurrent pregnancy loss (RPL) is a serious problem on the women, it defined as two or more consecutive pregnancy losses before the fetus has reached birth. The aim of this study is to evaluate the association between the elevation in the factor VIII and RPL. Because women who have thrombophilia have increased risk of fetal loss in most studies.
Methods: A total 72 women were recruited in this case control study. They divided into two groups: the RPL group included 41 women with a history of recurrent pregnancy loss and the control group included 31 healthy women, who had at least one successful pregnancy and none of them had a history of fetal loss or complicated pregnancy.
Results: A majority of the patients of this study didn't have a high level of factor VIII, 9 of 41 (22%) patients of RPL group in comparison with 21 of 32 (65,6%) of control group, that suffer from the increase rate of FVIII, this means that factor VIII doesn't effect on RPL.
Conclusions: The present study showed that the serum elevation in the factor VIII is not significantly associated with RPL.
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References
Brenner B. Commentary: thrombophilia and pregnancy loss in first intended pregnancy. J Thrombosis Haemosta. 2005;3(10):2176-7.
Meka A, Reddy BM. Recurrent spontaneous abortions: an overview of genetic and non-genetic backgrounds. Int J Human Genet. 2006;6(2):109-17.
Pandey MK, Rani R, Agrawal S. An update in recurrent spontaneous abortion. Arch Gynecol Obstet. 2005;272(2):95-108.
Ford HB, Schust DJ. Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2009;2(2):76.
Garcıa-Enguıdanos A, Calle ME, Valero J, Luna S, Domınguez-Rojas V. Risk factors in miscarriage: a review. Eur J Obstet Gynecol Reprod Biol. 2002;102(2):111-9.
Ghumman S. Recurrent Miscarriage. World Clin Obstet Gynecol. 2011;1(1):70.
Allison JL, Schust DJ. Recurrent first trimester pregnancy loss: revised definitions and novel causes. Current Opin Endocrinol Diab Obes. 2009;16(6):446-50.
Cleary-Goldman J, Nakhuda GS, Zimmermann RC, Sauer MV. The role of factor V Leiden mutation in recurrent pregnancy loss. J Am Med Women's Associat. 2003;58(3):165-72.
Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID. Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thrombosis Haemostasis. 1998;79(6):1166-70.
Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Internal Med. 2004;164(5):558-63.
Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. The Lancet. 2003;361(9361):901-8.
Wu O, Robertson L, Twaddle S, Lowe GD, Clark P, Greaves M, Walker ID, et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The thrombosis: risk and economic assessment of thrombophilia screening (TREATS) study. Health Technol Assess. 2006;10(11):1-110.
Alhalaki WIA, Altanoukhi, Alhalabi M. The association of activated protein C resistance (aPCR) with recurrent pregnancy loss in syrian population. Inter J Pharma Sci Rev Res. 2016;38(151):290-5.
Brenner B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Haemos. 1999;82(7):6-9.
Brown, K., et al., Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′‐untranslated region of the prothrombin gene. Br J Haematol. 1997;98(4):907-9.
Walker ID, Greaves M, Preston F. Investigation and management of heritable thrombophilia. Br J Haematol. 2001;114(3):512-28.
Kraaijenhagen RA, Koopman MM, Reitsma PH, Prins MH, van den Ende A, Büller HR. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost. 2000;83(01):5-9.
van der Meer FJ, Koster T, Vandenbroucke JP, Briet E, Rosendaal FR. The Leiden thrombophilia study (LETS). Thromb Haemost. 1997;78(1):631-5.
Koster T, Vandenbroucke JP, Rosendaal FR, Briët E, Blann AD. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. The Lancet. 1995;345(8943):152-5.
Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88(10):3698-703.
Rodeghiero F, Tosetto A. The epidemiology of inherited thrombophilia: the VITA Project. Vicenza Thrombophilia and Atherosclerosis Project. Thromb Haemost. 1997;78(1):636.
Tizzano EF, Soria JM, Coll I, Guzmán B, Cornet M, Altisent C, et al. The prothrombin 20210A allele influences clinical manifestations of hemophilia A in patients with intron 22 inversion and without inhibitors. Haematol. 2002;87(3):279-85.
Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, et al. The thrombomodulin–protein C system is essential for the maintenance of pregnancy. Nature Med. 20039(3): p. 331.
Shetty S, Salvi V, Satoskar P, Ghosh K. Thrombophilia and unexplained pregnancy loss in Indian patients. National Med J India. 2008;21:116-9.
Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, et al. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature. 1984;312(5992):342-7.
Derrier, M. and A. Mercatello. Role of non-steroidal anti-inflammatory agents in the perioperative period. Usefulness and limitations. Ann Fr Anesth Reanim. 1997;16(5):498-520.
Jenkins PV, Rawley O, Smith OP, O'Donnell JS. Elevated factor VIII levels and risk of venous thrombosis. Br J Haematol. 2012;157(6):653-63.
Milne DB, Nielsen FH. Effects of a diet low in copper on copper-status indicators in postmenopausal women. The Am J Clin Nutrit. 1996;63(3):358-64.
Mohammadi MMA, Al-Halabi MG, Monem FMS. Prevalence of factor V leiden mutation and its relation with recurrent spontaneous pregnancy loss in a group of Syrian women. Middle East Fertil Society J. 2007;12(3):179.
Ali A, Pushpavalli Mohan HK, Muhammed MK. Elevated factor VIII levels and shortened APTT in recurrent abortions. J Clin Diagnos Res. JCDR. 2016;10(1):EC04.
Hansda J, Roychowdhury J. Study of thrombophilia in recurrent pregnancy loss. The J Obstet Gynecol India. 2012;62(5):536-40.
Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A. Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Human Reproduct. 2002;17(6):1633-7.
Abu- Abu-Asab NS, Ayesh SK, Ateeq RO, Nassar SM, El-Sharif WA. Association of inherited thrombophilia with recurrent pregnancy loss in palestinian women. Obstet Gynecol Inter. 2011;2011.
Patounakis G, Bergh E, Forman EJ, Tao X, Lonczak A, Franasiak JM, et al. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. J Assisted Reprod Genet. 2016;33(1):67-73.
Cardona H, Castañeda SA, Cardona Maya W, Alvarez L, Gómez J, Gómez J, et al. Lack of association between recurrent pregnancy loss and inherited thrombophilia in a group of Colombian patients. Thrombos. 2012;2012.